Large Rnas With A Purpose

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Large Rnas With A Purpose

机译：有目的的大型Rnas

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Mammalian genomes are transcribed to produce many large non-coding RNAs, but their function is unclear, in part because there is little evidence of evolutionary conservation. A new approach to characterizing these mysterious molecules has now moved the field on. Rather than targeting RNA molecules themselves, they were revealed as chromatin modifications or epigenomic marks in the DNA of four mouse cell types. The search yielded over a thousand large multi-exonic transcriptional units that do not overlap known protein-coding loci and are highly conserved.

机译：哺乳动物基因组被转录产生许多大的非编码RNA，但其功能尚不清楚，部分原因是几乎没有进化保守的证据。现在，表征这些神秘分子的新方法推动了这一领域的发展。它们不是靶向RNA分子本身，而是在四种小鼠细胞类型的DNA中显示为染色质修饰或表观基因组标记。该搜索产生了超过一千个大型多外显子转录单位，这些单位与已知的蛋白质编码基因座不重叠，并且高度保守。

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《Nature》 |2009年第7235期|p.121|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Large Rnas With A Purpose

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