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首页> 外文期刊>Nature >C-myc Suppression Of Mir-23a/b Enhances Mitochondrial Glutaminase Expression And Glutamine Metabolism
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C-myc Suppression Of Mir-23a/b Enhances Mitochondrial Glutaminase Expression And Glutamine Metabolism

机译：C-myc抑制Mir-23a / b增强线粒体谷氨酰胺酶表达和谷氨酰胺代谢。

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Altered glucose metabolism in cancer cells is termed the Warburg effect, which describes the propensity of most cancer cells to take up glucose avidly and convert it primarily to lactate, despite available oxygen. Notwithstanding the renewed interest in the Warburg effect, cancer cells also depend on continued mitochondrial function for metabolism, specifically glutaminolysis that catabolizes glutamine to generate ATP and lactate. Glutamine, which is highly transported into proliferating cells, is a major source of energy and nitrogen for biosynthesis, and a carbon substrate for anabolic processes in cancer cells, but the regulation of glutamine metabolism is not well understood. Here we report that the c-Myc (hereafter referred to as Myc) oncogenic transcription factor, which is known to regulate microRNAs and stimulate cell proliferation', transcriptionally represses miR-23a and miR-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells. This leads to upregulation of glutamine cata-bolism. Glutaminase converts glutamine to glutamate, which is further catabolized through the tricarboxylic acid cycle for the production of ATP or serves as substrate for glutathione synthesis. The unique means by which Myc regulates glutaminase uncovers a previously unsuspected link between Myc regulation of miRNAs, glutamine metabolism, and energy and reactive oxygen species homeostasis.
机译：癌细胞中葡萄糖代谢改变的现象被称为Warburg效应，它描述了大多数癌细胞倾向于摄取葡萄糖并将其主要转化为乳酸的倾向，尽管有可用的氧气。尽管人们对沃堡效应重新产生了兴趣，但癌细胞还依赖于线粒体持续的代谢功能，尤其是谷氨酰胺分解，谷氨酰胺分解代谢谷氨酰胺以生成ATP和乳酸。谷氨酰胺高度转移到增殖细胞中，是生物合成的主要能量和氮源，也是癌细胞合成代谢过程的碳底物，但对谷氨酰胺代谢的调节尚不甚了解。在这里，我们报道了已知的c-Myc（以下称为Myc）致癌转录因子，它调控microRNA并刺激细胞增殖，在转录上抑制miR-23a和miR-23b，从而导致其靶蛋白的更高表达，人P-493 B淋巴瘤细胞和PC3前列腺癌细胞中的线粒体谷氨酰胺酶。这导致谷氨酰胺分解代谢的上调。谷氨酰胺酶将谷氨酰胺转化为谷氨酸，谷氨酸通过三羧酸循环进一步分解代谢以产生ATP或用作谷胱甘肽合成的底物。 Myc调节谷氨酰胺酶的独特方法揭示了Myc对miRNA的调节，谷氨酰胺代谢与能量和活性氧稳态之间的联系。

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