Low-risk Reprogramming

Martin F. Pera

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Low-risk Reprogramming

机译：低风险的重新编程

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Shinya Yamanaka's amazing discovery1 that cells from differentiated tissues can be repro-grammed into induced pluripotent stem (iPS) cells-cells that can potentially differentiate into any cell type-has transformed research in stem-cell biology and regenerative, medicine. The breakthrough provided both a deft approach to the production of patient-specific stem-cell lines with which to study disease, and a practical means of developing large banks of stem-cell lines suitable for tissue matching in transplantation therapy. But the original protocols for producing iPS cells relied on the integration of foreign 'reprogramming' genes into the host-cell genome, a process associated with risks including mutation, dysregulation of native gene expression, and the development of cancers after iPS-cell transplantation. Four studies2"5, including two in this issue2'3, now show that iPS cells can be produced without any permanent modification to the host-cell genome.

机译：山中伸弥（Shinya Yamanaka）的惊人发现[1]可以将来自分化组织的细胞重新编程为诱导性多能干（iPS）细胞-可以分化为任何细胞类型的细胞-已转变为干细胞生物学和再生医学研究。突破性进展既提供了一种灵巧的方法来生产可用于研究疾病的患者特异性干细胞系，又提供了一种开发适合于移植治疗中组织匹配的大量干细胞系的实用方法。但是生产iPS细胞的原始协议依赖于将外源“重编程”基因整合到宿主细胞基因组中，该过程与风险相关，包括突变，天然基因表达失调以及iPS细胞移植后癌症的发展。现在有四项研究2“ 5，包括本期2'3中的两项研究，表明可以生产iPS细胞而无需对宿主细胞基因组进行任何永久性修饰。

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《Nature》 |2009年第7239期|715-716|共2页
作者
Martin F. Pera;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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2. Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules [J] . Kei Miyamoto, Tomomi Tsujikawa, Kazuo Yamagata, Biology Open . 2017,第4期

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3. BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling [J] . Heike Depner, Ichie Steinfeld, Paul G. Layer, Biology Open . 2017,第7期

机译：BMP诱导的神经视网膜重编程为视网膜色素上皮需要Wnt信号BMP诱导的神经视网膜重编程为视网膜色素上皮需要Wnt信号BMP诱导的神经视网膜重编程为视网膜色素上皮需要Wnt信号
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机译：低风险患者的P1816脑微栓栓患者肺静脉患者肺静脉分离术前后患者阵发性心房颤动的低危患者

Low-risk Reprogramming

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