Making The Paper

Susan Lea

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Making The Paper

机译：造纸

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Although relatively uncommon, meningitis -inflammation of the membranes covering the brain and spinal cord - can kill within hours. Immediately after infection, one major bacterial culprit - Neisseria meningitidis - coats itself with a human protein so that immune cells no longer recognize it as an intruder. Using X-ray crystallography, Susan Lea of the University of Oxford, UK, and her colleagues now describe the interaction between the microbe and the human protein. Christoph Tang at Imperial College London had previously discovered that N. meningitidis uses a protein on its surface, dubbed factor-H-binding protein, to grasp hold of the human protein factor H. "Chris contacted us hoping that we could help to characterize these interactions further," recalls Lea.

机译：脑膜炎-覆盖大脑和脊髓的膜发炎-尽管相对罕见，但可以在数小时内杀死。感染后，一种主要的细菌元凶-脑膜炎奈瑟氏球菌（Neisseria meningitidis）用人蛋白包被，因此免疫细胞不再将其识别为入侵者。英国牛津大学的Susan Lea和她的同事们使用X射线晶体学描述了微生物和人类蛋白质之间的相互作用。伦敦帝国理工学院的Christoph Tang先前发现脑膜炎奈瑟氏球菌在其表面使用一种称为H因子结合蛋白的蛋白质来抓住人类蛋白质H因子。“ Chris与我们联系，希望我们可以帮助表征这些蛋白质。互动。” Lea回忆道。

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《Nature》 |2009年第7240期|p.805|共1页
作者
Susan Lea;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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Making The Paper

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