首页> 外文期刊>Nature >Select Drosophila glomeruli mediate innate olfactory attraction and aversion
【24h】

Select Drosophila glomeruli mediate innate olfactory attraction and aversion

机译:选择果蝇肾小球介导先天的嗅觉吸引和厌恶。

获取原文
获取原文并翻译 | 示例
           

摘要

Fruitflies show robust attraction to food odours, which usually excite several glomeruli. To understand how the representation of such odours leads to behaviour, we used genetic tools to dissect the contribution of each activated glomerulus. Apple cider vinegar triggers robust innate attraction at a relatively low concentration, which activates six glomeruli. By silencing individual glomeruli, here we show that the absence of activity in two glomeruli, DM1 and VA2, markedly reduces attraction. Conversely, when each of these two glomeruli was selectively activated, flies showed as robust an attraction to vinegar as wild-type flies. Notably, a higher concentration of vinegar excites an additional glomerulus and is less attractive to flies. We show that activation of the extra glomerulus is necessary and sufficient to mediate the behavioural switch. Together, these results indicate that individual glomeruli, rather than the entire pattern of active glomeruli, mediate innate behavioural output.
机译:果蝇对食物的气味显示出强烈的吸引力,通常会刺激一些肾小球。为了了解这种气味的表示方式如何导致行为,我们使用遗传工具剖析了每个活化肾小球的作用。苹果醋在较低的浓度下会触发强大的先天吸引,从而激活六个肾小球。通过沉默单个肾小球,我们在这里显示出在两个肾小球DM1和VA2中缺乏活性会明显降低吸引力。相反,当选择性激活这两个肾小球中的每一个时,果蝇显示出对醋的吸引力与野生型果蝇一样强。值得注意的是,较高浓度的醋会刺激其他肾小球,并且对苍蝇的吸引力较小。我们表明激活多余的肾小球是必要和足够的,以介导行为转换。总之,这些结果表明单个肾小球而不是活动性肾小球的整个模式介导先天的行为输出。

著录项

  • 来源
    《Nature》 |2009年第7244期|218-223|共6页
  • 作者单位

    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA;

    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号