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Immunity's ancient arms

机译:豁免权的远古武器

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摘要

Diverse receptors on two types of cell mediate adaptive immunity in jawed vertebrates. In the lamprey, a jawless vertebrate, immunity is likewise compartmentalized but the molecular mechanics are very different.rnAbout 500 million years ago, vertebrates divided into two forms marked by the possession or lack of jaws. Today, the jawed forms are by far the more common and include organisms as diverse as humans and sharks. Immunology research has understandably centred on the jawed vertebrates, in which it has long been known that adaptive (inducible) immunity is mainly accounted for by two distinct lineages of lymphocyte: T cells and B cells.
机译:在颌骨脊椎动物中,两种细胞上的不同受体介导适应性免疫。在七角鳗(一种无颚的脊椎动物)中,免疫力同样具有分隔性,但分子机制却截然不同。大约在五亿年前,脊椎动物被分为两种形式,以拥有或缺乏颚骨为特征。时至今日,颚状形式已变得更为普遍,其中包括人类和鲨鱼等多种生物。免疫学研究集中在有颚的脊椎动物上,这是可以理解的,长期以来人们就知道适应性(诱导)免疫主要是由淋巴细胞的两个不同谱系造成的:T细胞和B细胞。

著录项

  • 来源
    《Nature》 |2009年第7248期|784-786|共3页
  • 作者

    Gary W. Litman; John P. Cannon;

  • 作者单位

    Children's Research Institute, St Petersburg, Florida 33701, USA;

    Children's Research Institute, St Petersburg, Florida 33701, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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