Sirtuins and longevity

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Sirtuins and longevity

机译：Sirtuins和长寿

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The sirtuins, conserved NAD~+-dependent deacetylases or ADP-ribosyltransferases, promote longevity in many organisms, though the mechanisms involved are poorly understood. For example, the yeast sirtuin Sir2 is known to deacetylate lysine 16 in histone H4, but it was not clear if this relates to Sir2's anti-ageing role. Dang et al. now report an age-associated decrease in Sir2 protein abundance that is associated with increased H4 lysine 16 acetylation and a loss of histones, impairing transcriptional silencing at specific subtelomeric regions in replicatively old yeast cells.

机译：Sirtuins，保守的NAD +依赖性脱乙酰基酶或ADP-核糖基转移酶，虽然许多机制尚不清楚，但它们可促进许多生物的寿命。例如，已知酵母沉默调节蛋白Sir2使组蛋白H4中的赖氨酸16脱乙酰基，但是尚不清楚这是否与Sir2的抗衰老作用有关。党等现在报道了与年龄相关的Sir2蛋白丰度下降，这与H4赖氨酸16乙酰化增加和组蛋白丢失有关，从而损害了复制性旧酵母细胞中特定亚端粒区域的转录沉默。

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《Nature》 |2009年第7248期|748-748|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians [J] . Acupuncture & electro-therapeutics research . 2011,第3a4期

机译：关于疾病，健康和长寿的长寿基因的新临床发现：Sirtuin 1经常随着年龄的增长和人体大多数部位的严重疾病而减少，而相对高而恒定的sirtuin 1却不分年龄，首先在人的海马中发现。超级百岁老人
2. Cell Longevity of Yeast Saccharomyces cerevisiae by Clove Bud Extract Treatment May Occur in Sirtuin-Independent Pathway [J] . Zahrah Qolbaina Ariybah, Rika Indri Astuti, Sri Listiyowati Online journal of biological sciences . 2021,第3期

机译：丁香芽提取物治疗的酵母酿酒酵母酿酒酵母的细胞寿命可能发生在SIRTUIN的独立途径中
3. Beyond longevity: novel roles of Sirtuin-3 in thrombosis [J] . Ramos Gustavo, Frantz Stefan Cardiovascular Research . 2018,第8期

机译：超越寿命：Sirtuin-3在血栓形成的新角色
4. Evolutionary Conservation of Sirtuin Lipoamidase Activity from Bacteria to Human Mitochondria [C] . Elizabeth Rowland, Todd Greco, Caroline Snowden, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：从细菌到人体线粒体的Sirtuin Lipoida酶活性的进化保护
5. Hormonal Regulation of Sirtuins Activity and Expression in Bovine Granulosa Cells [D] . Archilia, Evandro Carlos. 2021

机译：牛颗粒细胞的荷鲁林活性和表达的激素调节
6. Do Sirtuins Promote Mammalian Longevity?: A Critical Review on Its Relevance to the Longevity Effect Induced by Calorie Restriction [O] . Seongjoon Park, Ryoichi Mori, Isao Shimokawa 2013

机译：Sirtuins会促进哺乳动物的长寿吗？：关于它与卡路里限制引起的长寿效应的相关性的批判性评论
7. Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China [O] . Yao Yao, Linxin Liu, Guang Guo, 2021

机译：Sirtuin 1（SIRT1）候选寿命基因和颗粒物质（PM2.5）对全导致死亡率的相互作用：中国纵向队列研究

Sirtuins and longevity

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