The proteasome assembly line

Kiran Madura

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The proteasome assembly line

机译：蛋白酶体组装线

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The assembly of the proteasome - the cellular machine that eliminates unwanted proteins - is a carefully choreographed affair, involving a complex sequence of steps overseen by dedicated protein chaperones.rnThe proteasome degrades faulty or superfluous intracellular proteins, which are targeted to it for destruction by the attachment of the small ubiquitin protein. This multi-protein complex consists of a barrel-shaped core particle, which enzymatically degrades proteins, bound to one or two outer regulatory particles. The regulatory particle binds and unfolds ubiquitin-tagged proteins and transfers them to the catalytic chamber of the core particle. Whereas the assembly pathway of the core particle is quite well understood, little is known about how the regulatory particle is put together.

机译：蛋白酶体的组装-一种消除有害蛋白质的细胞机器-是精心编排的事务，涉及专用蛋白分子伴侣监督的复杂步骤序列。蛋白酶体降解有缺陷或多余的细胞内蛋白质，将其靶向并被细胞破坏。小泛素蛋白的附着。这种多蛋白复合物由桶形核心颗粒组成，该核心颗粒通过酶促降解方式与一个或两个外部调节颗粒结合在一起，从而降解蛋白质。调节颗粒结合并展开遍在蛋白标记的蛋白，并将其转移到核心颗粒的催化室。尽管核心颗粒的组装途径已被很好地理解，但对于调节颗粒如何组合在一起却知之甚少。

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来源
《Nature》 |2009年第7248期|787-788|共2页
作者
Kiran Madura;
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作者单位

Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Mouse zygote-specific proteasome assembly chaperone important for maternal-to-zygotic transition Mouse zygote-specific proteasome assembly chaperone important for maternal-to-zygotic transition Mouse zygote-specific proteasome assembly chaperone important for maternal-to-zygotic transition [J] . Shigeo Murata, Seung-Wook Shin, Natsumi Shimizu, Biology Open . 2013,第2期

机译：小鼠合子特异性蛋白酶体组装伴侣对母体向合子的过渡很重要小鼠合子特异性蛋白酶体组装伴侣对母体向合子的过渡很重要
2. AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation [J] . Jianhui Li, Michal Breker, Morven Graham, PLoS Genetics . 2019,第11期

机译：AMPK调节葡萄糖饥饿期间伴随蛋白酶体存储颗粒组装的蛋白酶体的ESCRT依赖性微自噬。
3. Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation [J] . Kurimoto Eiji, Satoh Tadashi, Ito Yuri, Protein Science: A Publication of the Protein Society . 2017,第5期

机译：人类蛋白酶组件伴侣伴蛋白质组合伴侣蛋白组合伴蛋白酶体形成的晶体结构
4. Preincubation with the Proteasome Inhibitor MG-132 Enhances Proteasome Activity via the Nrf2 Transcription Factor in Aging Human Skin Fibroblasts [C] . DAVID CHRISTIAN KRAFT, CUSTER C. DEOCARIS, RENU WADHWA, International Association of Biomedical Gerontology International . 2006

机译：用蛋白酶体抑制剂Mg-132预孵育通过老化人体皮细胞的NRF2转录因子增强蛋白酶体活性
5. Architecture and assembly of the 19S proteasome regulatory particle [D] . Estrin, Eric 2014

机译：19S蛋白酶体调控颗粒的结构和组装
6. Molecular and Structural Basis of the Proteasome α Subunit Assembly Mechanism Mediated by the Proteasome-Assembling Chaperone PAC3-PAC4 Heterodimer [O] . Tadashi Satoh, Maho Yagi-Utsumi, Kenta Okamoto, 2019

机译：蛋白酶体伴侣伴侣PAC3-PAC4异二聚体介导的蛋白酶体α亚基组装机理的分子和结构基础
7. Difference between PA700-like proteasome activator complex and the regulatory complex dissociated from the 26S proteasome implies the involvement of modulating factors in the 26S proteasome assembly [O] . Sawada Hitoshi, Akaishi Takahiro, Katsu Masataka, 1997

机译：类似于PA700的蛋白酶体激活物复合物与从26S蛋白酶体解离的调节复合物之间的差异表明调节因子参与了26S蛋白酶体组装

The proteasome assembly line

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