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首页> 外文期刊>Nature >Yurtf Coracle, Neurexin IV and the Na~+,K~+-ATPase form a novel group of epithelial polarity proteins
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Yurtf Coracle, Neurexin IV and the Na~+,K~+-ATPase form a novel group of epithelial polarity proteins

机译：Yurtf Coracle，Neurexin IV和Na〜+，K〜+ -ATPase组成了一组新的上皮极性蛋白

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摘要

The integrity of polarized epithelia is critical for development and human health. Many questions remain concerning the full complement and the function of the proteins that regulate cell polarity1. Here we report that the Drosophila PERM proteins Yurt (Yrt) and Coracle (Cora) and the membrane proteins Neurexin IV (Nrx-IV) and Na~+,K~+-ATPase are a new group of functionally cooperating epithelial polarity proteins. This 'Yrt/ Cora group' promotes basolateral membrane stability and shows negative regulatory interactions with the apical determinant Crumbs (Crb). Genetic analyses indicate that Nrx-IV and Na~+,K~+-ATPase act together with Cora in one pathway, whereas Yrt acts in a second redundant pathway. Moreover, we show that the Yrt/Cora group is essential for epithelial polarity during organogenesis but not when epithelial polarity is first established or during terminal differentiation. This property of Yrt/Cora group proteins explains the recovery of polarity in embryos lacking the function of the Lethal giant larvae (Lgl) group of basolateral polarity proteins. We also find that the mammalian Yrt orthologue EPB41L5 (also known as YMO1 and Limulus) is required for lateral membrane formation, indicating a conserved function of Yrt proteins in epithelial polarity.
机译：极化上皮细胞的完整性对于发展和人类健康至关重要。关于调节细胞极性的蛋白质的完整补体和功能，仍然存在许多问题。在这里，我们报告果蝇PERM蛋白Yurt（Yrt）和Coracle（Cora）和膜蛋白Neurexin IV（Nrx-IV）和Na〜+，K〜+ -ATPase是功能上合作的上皮极性蛋白的新组。这个“ Yrt / Cora组”促进了基底外侧膜的稳定性，并显示出与根尖决定簇Crumbs（Crb）的负调节相互作用。遗传分析表明，Nrx-IV和Na〜+，K〜+ -ATPase在一条途径中与Cora共同起作用，而Yrt在另一条冗余途径中起作用。此外，我们显示，Yrt / Cora基团对于器官发生过程中的上皮极性必不可少，但不是在首次建立上皮极性时或在终末分化过程中。 Yrt / Cora组蛋白的这种特性解释了缺乏基底外侧极性蛋白的致命巨型幼虫（Lgl）组功能的胚胎中极性的恢复。我们还发现，哺乳动物的Yrt直系同源物EPB41L5（也称为YMO1和Li）是形成侧向膜所必需的，表明Yrt蛋白在上皮极性中具有保守的功能。

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  • 来源
    《Nature》 |2009年第25期|1141-1145|共5页
  • 作者

    Patrick Laprise; Kimberly M. Lau; Kathryn P. Harris; Nancy F. Silva-Gagliardi; Sarah M. Paul; Slobodan Beronja; Greg J. Beitel; C. Jane McGlade; Ulrich Tepass;

  • 作者单位

    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada;

    Department of Medical Biophysics, University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada;

    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada;

    Department of Medical Biophysics, University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada;

    Department of Biochemistry, Molecular Biology and Cell Biology,Northwestern University, Evanston, Illinois 60208, USA.;

    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada;

    Department of Biochemistry, Molecular Biology and Cell Biology,Northwestern University, Evanston, Illinois 60208, USA.;

    Department of Medical Biophysics, University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada;

    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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