Metalloproteins and metal sensing

Kevin J. Waldron; Julian C. Rutherford; Dianne Ford; Nigel J. Robinson

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Metalloproteins and metal sensing

机译：金属蛋白和金属感测

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Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells. Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.

机译：所有酶中几乎有一半必须与特定金属缔合才能发挥作用。雄心壮志是要理解为什么每种金属-蛋白质伙伴关系产生以及如何维持这种关系。金属的可用性提供了部分解释，并且随着地质时间的变化而变化，生境之间也有所不同，但被限制在细胞的重要范围之内。这种动态平衡需要金属传感器，并且正在进行探索以发现金属传感机制。为了使金属蛋白获得合适的金属，金属传感器必须正确地区分无机元素。

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来源
《Nature》 |2009年第7257期|823-830|共8页
作者
Kevin J. Waldron; Julian C. Rutherford; Dianne Ford; Nigel J. Robinson;
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作者单位

Cell & Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK;

Cell & Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK;

Cell & Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK;

Cell & Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Metalloproteins: structure and function-Metal sensing in a bacterial cell: a network that differentiates metals [J] . Cecilia Piergentili, Andrew W. Foster, Carl J. Patterson, Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry . 2014,第Null期

机译：金属蛋白：结构和功能-细菌细胞中的金属感测：区分金属的网络
2. Metalloproteins: structure and function-Metalloprotein manipulation for metal biosensors and bio-recovery [J] . Wei Wei, Xiangzhi Liu, Peiqing Sun, Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry . 2014,第Null期

机译：金属蛋白：结构和功能-金属蛋白传感器的金属生物传感器和生物回收
3. Metalloprotein-inhibitor binding: Human carbonic anhydrase II as a model for probing metal-ligand interactions in a metalloprotein active site [J] . Martin D.P., Hann Z.S., Cohen S.M. Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2013,第21期

机译：金属蛋白抑制剂结合：人类碳酸酐酶II作为探测金属蛋白活性位点中金属-配体相互作用的模型
4. Metalloprotein Microscopy for Quantitative Imaging of Metals and Metallomics Studies in Neurosciences [C] . J. Sabine Becker, Bei Wu, Stefan Niehren, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：金属蛋白显微镜，用于神经科学的金属和金属化学研究的定量成像
5. Investigations on the conformational stability and metal substitution of the zinc ion-dependent anthrax lethal factor protease and new strategies for the quantification of divalent metal ions in metalloproteins. [D] . Sabel, Crystal Elizabeth. 2011

机译：锌离子依赖性炭疽致死因子蛋白酶的构象稳定性和金属取代的研究以及定量金属蛋白中二价金属离子的新策略。
6. Fluorescence Patterns from Supramolecular Polymer Assembly and Disassembly for Sensing of Metallo- and Non-metalloproteins [O] . Daniella C. González, Elamprakash N. Savariar, S. Thayumanavan -1

机译：从超分子聚合物装拆的金属 - 传感和非荧光金属蛋白模式
7. Metalloprotein–Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal–Ligand Interactions in a Metalloprotein Active Site [O] . David P. Martin, Zachary S. Hann, Seth M. Cohen 2013

机译：金属蛋白抑制剂结合：人碳酸酐酶II作为探测金属蛋白活性位点的金属 - 配体相互作用的模型

Metalloproteins and metal sensing

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