The logic of chromatin architecture and remodelling at promoters

Bradley R. Cairns

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The logic of chromatin architecture and remodelling at promoters

机译：染色质结构和启动子重塑的逻辑

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The regulation of gene transcription involves a dynamic balance between packaging regulatory sequences into chrornatin and allowing transcriptional regulators access to these sequences. Access is restricted by the nucleosomes, but these can be repositioned or ejected by enzymes known as nucleosome remodellers. In addition, the DNA sequence can impart stiffness or curvature to the DNA, thereby affecting the position of nucleosomes on the DNA, influencing particular promoter 'architectures'. Recent genome-wide studies in yeast suggest that constitutive and regulated genes have architectures that differ in terms of nucleosome position, turnover, remodelling requirements and transcriptional noise.

机译：基因转录的调控涉及在将调控序列包装入角蛋白中并允许转录调控因子接近这些序列之间的动态平衡。进入受核小体的限制，但是这些可以被称为核小体重塑剂的酶重新定位或弹出。另外，DNA序列可以赋予DNA刚性或弯曲度，从而影响核小体在DNA上的位置，影响特定的启动子“结构”。最近在酵母中进行的全基因组研究表明，组成型和调控型基因的结构在核小体位置，更新，重塑要求和转录噪声方面均不同。

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来源
《Nature》 |2009年第7261期|193-198|共6页
作者
Bradley R. Cairns;
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作者单位

Howard Hughes Medical Institute, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Artificially Recruited TATA-Binding Protein Fails To Remodel Chromatin and Does Not Activate Three Promoters That Require Chromatin Remodeling [J] . Michael P. Ryan, Grace A. Stafford, Liuning Yu, Molecular and Cellular Biology . 2000,第16期

机译：人工招募的TATA结合蛋白无法重塑染色质，并且不会激活需要染色质重塑的三个启动子
2. Genome-Wide Mapping Targets of the Metazoan Chromatin Remodeling Factor NURF Reveals Nucleosome Remodeling at Enhancers, Core Promoters and Gene Insulators [J] . So Yeon Kwon, Valentina Grisan, Boyun Jang, PLoS Genetics . 2016,第4期

机译：后生动物染色质重塑因子NURF的全基因组定位目标揭示了增强子，核心启动子和基因绝缘子的核小体重塑。
3. The RSC remodeling complex as essential component of the remodeler network for chromatin remodeling at the yeast PHO5 promoter [J] . Musladin S., Hlevnjak D., Krietenstein N., The FEBS journal . 2014,第Suppla1期

机译：RSC重塑复合体是酵母PHO5启动子上染色质重塑的重塑网络的重要组成部分
4. Chromatin signature analysis and prediction of genome-wide novel promoters using finite mixture model [C] . Taslim Cenny, Lin Shili, Huang Kun, Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on . 2011

机译：染色质特征分析和全基因组新启动子的有限混合模型预测
5. Molecular mechanism of the recruitment of SWI/SNF chromatin remodeling complex and histone acetyltransferase to estrogen-responsive promoters. [D] . Jeong, KwangWon. 2010

机译：SWI / SNF染色质重塑复合物和组蛋白乙酰转移酶募集到雌激素反应性启动子的分子机制。
6. Artificially Recruited TATA-Binding Protein Fails To Remodel Chromatin and Does Not Activate Three Promoters That Require Chromatin Remodeling [O] . Michael P. Ryan, Grace A. Stafford, Liuning Yu, 2000

机译：人工招募的TATA结合蛋白无法重塑染色质并且不会激活需要染色质重塑的三个启动子
7. Artificially Recruited TATA-Binding Protein Fails To Remodel Chromatin and Does Not Activate Three Promoters That Require Chromatin Remodeling [O] . Ryan, Michael P., Stafford, Grace A., Yu, Liuning, 2000

机译：人工招募的TATA结合蛋白无法重塑染色质，并且不会激活需要染色质重塑的三个启动子

The logic of chromatin architecture and remodelling at promoters

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