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首页> 外文期刊>Nature >The abscisic acid receptor PYR1 in complex with abscisic acid
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The abscisic acid receptor PYR1 in complex with abscisic acid

机译：脱落酸受体PYR1与脱落酸复合

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摘要

The plant hormone abscisic acid (ABA) has a central role in coordinating the adaptive response in situations of decreased water availability as well as the regulation of plant growth and development. Recently, a 14-member family of intracellular ABA receptors, named PYR/PYL/RCAR, has been identified. These proteins inhibit in an ABA-dependent manner the activity of a family of key negative regulators of the ABA signalling pathway: the group-A protein phosphatases type 2C (PP2CS). Here we present the crystal structure of Arabidopsis thaliana PYR1, which consists of a dimer in which one of the subunits is bound to ABA. In the ligand-bound subunit, the loops surrounding the entry to the binding cavity fold over the ABA molecule, enclosing it inside, whereas in the empty subunit they form a channel leaving an open access to the cavity, indicating that conformational changes in these loops have a critical role in the stabilization of the hormone-receptor complex. By providing structural details on the ABA-binding pocket, this work paves the way for the development of new small molecules able to activate the plant stress response.
机译：植物激素脱落酸（ABA）在水利用量减少以及植物生长发育调节的情况下，在协调适应性反应中起着核心作用。最近，已经鉴定出一种名为PYR / PYL / RCAR的14成员的细胞内ABA受体家族。这些蛋白质以ABA依赖性方式抑制ABA信号传导途径的一系列关键负调控因子的活性：A组蛋白2C型磷酸酶（PP2CS）。在这里，我们介绍拟南芥PYR1的晶体结构，该结构由其中一个亚基与ABA结合的二聚体组成。在与配体结合的亚基中，结合腔入口周围的环在ABA分子上折叠，将其封闭在内部，而在空的亚基中，它们形成通道，向腔开放，表明这些环的构象变化在激素受体复合物的稳定中起关键作用。通过在ABA结合口袋上提供结构细节，这项工作为开发能够激活植物胁迫反应的新小分子铺平了道路。

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  • 来源
    《Nature》 |2009年第7273期|665-668|共4页
  • 作者

    Julia Santiago; Florine Dupeux; Adam Round; Regina Antoni; Sang-Youl Park; Marc Jamin; Sean R. Cutler; Pedro Luis Rodriguez; Jose Antonio Marquez;

  • 作者单位

    Institute de Biologia Molecular y Celular de Piantas, Consejo Superior de Investigaciones Cientificas-Universidad Politecnica de Valencia, ES-46022 Valencia, Spain;

    European Molecular Biology Laboratory, Grenoble Outstation and Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France;

    European Molecular Biology Laboratory, Grenoble Outstation and Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France;

    Institute de Biologia Molecular y Celular de Piantas, Consejo Superior de Investigaciones Cientificas-Universidad Politecnica de Valencia, ES-46022 Valencia, Spain;

    Department of Botany and Plant Sciences. Center for Plant Cell Biology University of California, Riverside, California 92521, USA;

    Virus Host Cell Interactions (UVHCI) UMI 3265, Universite Joseph Fourier-EMBL-CNRS, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France;

    Department of Botany and Plant Sciences. Center for Plant Cell Biology University of California, Riverside, California 92521, USA;

    Institute de Biologia Molecular y Celular de Piantas, Consejo Superior de Investigaciones Cientificas-Universidad Politecnica de Valencia, ES-46022 Valencia, Spain;

    European Molecular Biology Laboratory, Grenoble Outstation and Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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