Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

Dieter Wicher; Ronny Schaefer; Rene Bauernfeind; Marcus C. Stensmyr; Regine Heller; Stefan H. Heinemann; Bill S. Hansson

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Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

机译：果蝇气味受体是配体门控和环状核苷酸激活的阳离子通道

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From worm to man, many odorant signals are perceived by the binding of volatile ligands to odorant receptors that belong to the G-protein-coupled receptor (GPCR) family. They couple to heterotrimeric G-proteins, most of which induce cAMP production. This

机译：从蠕虫到人，挥发性配体与属于G蛋白偶联受体（GPCR）家族的气味受体的结合会感知到许多气味信号。它们与异源三聚体G蛋白偶联，其中大多数诱导cAMP产生。这个

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来源
《Nature》 |2008年第7190期|p.1007-1011|共5页
作者
Dieter Wicher; Ronny Schaefer; Rene Bauernfeind; Marcus C. Stensmyr; Regine Heller; Stefan H. Heinemann; Bill S. Hansson;
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作者单位

Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans-KnoeII-St 8, D-07745 Jena, Germany;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABA_A and serotonin receptors [J] . Zuzana Dostalova, Aiping Liu, Xiaojuan Zhou, Protein Science: A Publication of the Protein Society . 2010,第9期

机译：Cys环配体门控离子通道在四环素诱导的稳定哺乳动物细胞系中的高表达和纯化：GABA_A和5-羟色胺受体
2. Mutational studies using a cation-conducting GABAA receptor reveal the selectivity determinants of the Cys-loop family of ligand-gated ion channels. [J] . Jensen ML, Pedersen LN, Timmermann DB, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2005,第4期

机译：使用阳离子导电GABAA受体的突变研究揭示了配体门控离子通道Cys环家族的选择性决定因素。
3. Odorant receptors of Drosophila are sensitive to the molecular volume of odorants [J] . Majid Saberi, Hamed Seyed-allaei Scientific reports. . 2016,第1期

机译：果蝇的气味受体对气味剂的分子量敏感
4. Improving odorant chemical class prediction with multi-layer perceptrons using temporal odorant spike responses from drosophila melanogaster olfactory receptor neurons [C] . Luqman R. Bachtiar, Richard D. Newcomb, Andrew V. Kralicek, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2016

机译：使用果蝇嗅觉受体神经元的瞬时气味尖峰响应，通过多层感知器改善气味化学类别的预测
5. Chemical-scale studies of g protein-coupled receptors and ligand-gated ion channels. [D] . Van Arnam, Ethan Buggie. 2014

机译：g蛋白偶联受体和配体门控离子通道的化学规模研究。
6. Functional co-assembly among subunits of cyclic-nucleotide-activated nonselective cation channels and across species from nematode to human. [O] . J T Finn, D Krautwurst, J E Schroeder, 1998

机译：在环核苷酸激活的非选择性阳离子通道的亚基之间以及从线虫到人类的整个物种之间的功能性共装配。
7. High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors [O] . Dostalova, Zuzana, Liu, Aiping, Zhou, Xiaojuan, 2010

机译：Cys环配体门控离子通道在四环素诱导的稳定哺乳动物细胞系中的高表达和纯化：GABAA和5-羟色胺受体

Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

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