Power sequencing

Brenton R. Graveley

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Power sequencing

机译：电源排序

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Advances in DNA-sequencing technology provide unprecedented insight into the entire collection of four genomes' transcribed sequences. They herald a new era in the study of gene regulation and genome function.rnGenomes are the blueprints of life: they contain all the information necessary to build and operate their hosts. But we still have much to learn about the language of DNA to interpret the billions of Gs, As, Ts and Cs, the DNA bases that spell out life. The information-containing portions of genomes are transcribed into two RNA classes: messenger RNAs, which are translated into proteins; and non-coding RNAs, which have regulatory and mechanical roles. So studying the transcribed portion of the genome - the transcriptome - significantly aids gene identification, as well as providing insight into the inner workings of the genome and the biology of an organism. Five recent papers, including one on page 1239 of this issue by Wilhelm et al. describe how advances in DNA-sequencing technology can be harnessed to explore transcriptomes in remarkable detail.

机译：DNA测序技术的进步为四个基因组转录序列的整个集合提供了空前的洞察力。他们开启了基因调控和基因组功能研究的新纪元。基因组是生命的蓝图：它们包含构建和操作宿主的所有必要信息。但是，我们仍然需要学习很多有关DNA的语言，以解释数十亿个Gs，As，Ts和Cs，这些DNA可以说明生命。基因组中包含信息的部分被转录为两类RNA：信使RNA，被翻译成蛋白质；信使RNA，被翻译成蛋白质。以及具有调节和机械作用的非编码RNA。因此，研究基因组的转录部分-转录组-大大有助于基因鉴定，并提供对基因组内部工作原理和有机体生物学的见识。最近有五篇论文，其中包括Wilhelm等人在本期第1239页上发表的一篇论文。描述如何利用DNA测序技术的进步来详细探索转录组。

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《Nature》 |2008年第7198期|1197-1198|共2页
作者
Brenton R. Graveley;
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作者单位

Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center,Farmington, Connecticut 06030, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Paternity testing using massively parallel sequencing massively parallel sequencing and the PowerSeq? AUTO/Y system for short tandem repeat sequencing [J] . S. B. S. Silva Deborah, Sawitzki Fernanda R., Scheible Melissa K. R., Electrophoresis: The Official Journal of the International Electrophoresis Society . 2018,第21期

机译：父级测试使用大规模平行测序大规模平行测序和Powersq？自动/ y系统短串联重复排序
2. VIpower: Simulation-based tool for estimating power of viral integration detection via high-throughput sequencing [J] . Sulovari Arvis, Li Dawei Genomics . 2020,第1期

机译：摘要：基于仿真的工具，通过高吞吐量测序估算病毒集成检测的力量
3. VIpower: Simulation-based tool for estimating power of viral integration detection via high-throughput sequencing [J] . Arvis Sulovari, Dawei Li Genomics . 2020,第1期

机译：从高吞吐量测序估算病毒集成检测的仿真工具的基于仿真工具
4. Flow Index based Characterization of next Generation Sequencing Errors Visualizing Pyrosequencing and Semiconductor Sequencing to Cope with Homopolymer Errors [C] . Peter Sarkozy, Marton Enyedi, Peter Antal International Conference on Bioinformatics Models, Methods and Algorithms . 2014

机译：基于流量指数表征下一代测序误差可视化焦酶测序和半导体测序以应对均聚物误差
5. Bioinformatics: Using Computational Techniques (Whole Genome & Rna-Sequencing) to Understand Bacterial Genome Evolution and Biopharmaceutical Development =Bioinformatics: Using Computational Techniques (Whole Genome & RNA-Sequencing) to Understand Bac [D] . Duncan, David Jonith. 2020

机译：生物信息学：使用计算技术（全基因组和RNA测序）了解细菌基因组进化和生物制药发育=生物信息学：使用计算技术（全基因组＆amp; RNA测序）来理解BAC
6. Control of Acinetobacter baumannii outbreak in the neonatal intensive care unit in Latvia: whole-genome sequencing powered investigation and closure of the ward [O] . A. Gramatniece, I. Silamikelis, Ie. Zahare, 2019

机译：拉脱维亚新生儿重症监护病房中鲍曼不动杆菌爆发的控制：全基因组测序为研究提供动力并关闭病房
7. Polymer sequencing by molecular machines: A framework for predicting the resolving power of a sliding contact force spectroscopy sequencing method [O] . Dunlop Alex, Bowman Kate, Aarstad Olav, 2017

机译：分子机器对聚合物进行测序：预测滑动接触力光谱测序方法分辨能力的框架

Power sequencing

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