• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >THE NEXT SHOT
【24h】

THE NEXT SHOT

机译：下一张

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

As Larry Corey boarded a plane on the night of 18 September 2007, he was in shock. For four years, he had been in charge of clinical trials of a vaccine against HIV. Although previous vaccines had failed, Corey was optimistic that this one might work because it took a new approach. He thought it was the best hope against HIV. But that afternoon, Corey had met with scientists who had reviewed the early trial results. Not only did the vaccine not work, they told him, it might actually have made some people in the trial, called the STEP Study, more vulnerable to infection. On the long flight from Chicago home to Seattle that night, Corey cycled through stages of grief, regret and resolve. He had led the search for an HIV vaccine since its inception more than two decades ago. Now, as head of the flagship HIV Vaccine Trials Network run by the US National Institutes of Health (NIH), Corey had to make some difficult decisions. He had to decide what to tell the trial volunteers, and he had to think about the millions of other people who might contract HIV in the future. What could be done to make the vaccine that they so desperately needed?
机译：当拉里·科里（Larry Corey）在2007年9月18日晚上登上飞机时，他感到震惊。四年来，他一直负责抗艾滋病毒疫苗的临床试验。尽管以前的疫苗都失败了，但科里乐观地认为这种疫苗可能会奏效，因为它采用了新的方法。他认为这是对抗艾滋病毒的最大希望。但是那天下午，科里会见了审查早期试验结果的科学家。他们告诉他，不仅疫苗不起作用，实际上还可能使某些被称为“阶梯研究”的人更容易受到感染。那天晚上，在从芝加哥到西雅图的长途飞行中，科里经历了悲伤，遗憾和决心的各个阶段。自从二十多年前艾滋病病毒疫苗问世以来，他就一直在寻找它。现在，作为由美国国立卫生研究院（NIH）运营的旗舰HIV疫苗试验网络的负责人，Corey必须做出一些艰难的决定。他必须决定如何告知试验志愿者，还必须考虑未来可能感染艾滋病毒的数百万其他人。如何制造他们迫切需要的疫苗？

著录项

  • 来源
    《Nature》 |2008年第7204期|p.565-569|共5页
  • 作者

  • 作者单位
  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号