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Shrewd survival strategy

机译:精明的生存策略

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摘要

The bacterium that causes tuberculosis is one of the most successful pathogens. Its spread among humans has been so efficient that as much as one-third of the worlds population is now believed to be infected. In most cases, these infections cause clinically silent disease, which is likely to remain permanently dormant unless the host's immunity is substantially compromised. The extraordinary stealth and opportunism that Mycobacterium tuberculosis exhibits results from the complex and delicately coordinated way in which it interacts with its host - a process controlled in part by a specialized bacterial protein-secretion system called ESX-1.
机译:引起肺结核的细菌是最成功的病原体之一。它在人类中的传播是如此有效,以至于目前据信全世界多达三分之一的人口被感染。在大多数情况下,这些感染会导致临床上无声的疾病,除非宿主的免疫力受到重大损害,否则该疾病可能会永久休眠。结核分枝杆菌表现出的非凡的隐身性和机会主义是由于它与宿主相互作用的复杂而协调的方式所致-该过程部分受称为ESX-1的专门细菌蛋白分泌系统控制。

著录项

  • 来源
    《Nature》 |2008年第7205期|p.702-703|共2页
  • 作者

    Steven A. Porcelli;

  • 作者单位

    Departments of Microbiology and Immunology, and of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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