The latest suspect

Rudolph E. Tanzi; Lars Bertram

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The latest suspect

机译：最新嫌疑人

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Alzheimer's disease is characterized by neurodegeneration in several brain areas, with the hippocampus being one of the first regions affected. Accumulation of aggregates of the amyloid-β peptide, for example in the form of senile plaques, is another feature of this disorder. Dreses-Werringloer et al. set out to search for genes that are preferentially expressed in the hippocampus and lie in chromosomal regions that have been linked2 to the risk of developing Alzheimer's disease. Writing in Cell, they report the identification of a new Alzheimer's disease risk gene that not only meets both of these criteria, but also seems to modulate extracellular levels of amyloid-β.

机译：阿尔茨海默氏病的特征是在几个大脑区域发生神经退行性变，海马体是受影响的首批区域之一。该淀粉样蛋白-β肽聚集物的积累，例如以老年斑的形式，是这种疾病的另一个特征。 Dreses-Werringloer等。着手寻找优先在海马中表达且位于与发生阿尔茨海默氏病风险相关的染色体区域中的基因。他们在《细胞》杂志上写道，他们鉴定出了一个新的阿尔茨海默氏病风险基因，该基因不仅符合这两个标准，而且似乎还可以调节细胞外淀粉样β的水平。

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来源
《Nature》 |2008年第7205期|p.706-708|共3页
作者
Rudolph E. Tanzi; Lars Bertram;
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作者单位

Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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The latest suspect

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