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A topographic map of recruitment in spinal cord

机译:脊髓募集的地形图

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Animals move over a range of speeds by using rhythmic networks of neurons located in the spinal cord. Here we use electrophy-siology and in vivo imaging in larval zebrafish (Danio rerio) to reveal a systematic relationship between the location of a spinal neuron and the minimal swimming frequency at which the neuron is active. Ventral motor neurons and excitatory interneurons are rhythmically active at the lowest swimming frequencies, with increasingly more dorsal excitatory neurons engaged as swimming frequency rises. Inhibitory interneurons follow the opposite pattern. These inverted patterns of recruitment are independent of cell soma size among interneurons, but may be partly explained by concomitant dorso-ventral gradients in input resistance. Laser ablations of ventral, but not dorsal, excitatory interneurons perturb slow movements, supporting a behavioural role for the topography. Our results reveal an unexpected pattern of organization within zebrafish spinal cord that underlies the production of movements of varying speeds.
机译:通过利用位于脊髓中的神经元的有节奏的网络,动物可以在一定范围内移动。在这里,我们使用幼虫斑马鱼(Danio rerio)的电生理和体内成像来揭示脊髓神经元的位置和神经元活跃的最小游泳频率之间的系统关系。腹侧运动神经元和兴奋性中间神经元在最低游泳频率下具有节律性活动,随着游泳频率的增加,越来越多的背侧兴奋性神经元参与其中。抑制性中间神经元遵循相反的模式。这些募集的倒置模式与中间神经元之间的细胞体大小无关,但可能部分由输入阻力中的背-腹梯度引起。激光消融腹侧兴奋性神经元,但不刺激背侧兴奋性神经元,从而扰乱了缓慢的运动,从而支持了地形学的行为作用。我们的研究结果揭示了斑马鱼脊髓内一种意想不到的组织模式,它是产生不同速度运动的基础。

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