Tumour target

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Tumour target

机译：肿瘤靶

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Researchers have developed an animal model to test cancer drugs that target a tumour's blood supply. These drugs prevent blood-vessel growth in tumours by inhibiting a protein known as VEGF-A. Several drugs have been approved to treat specific forms of lung and colorectal cancer by this method.

机译：研究人员已经开发出一种动物模型来测试针对肿瘤血液供应的抗癌药物。这些药物通过抑制一种称为VEGF-A的蛋白质来防止肿瘤中血管的生长。已经通过这种方法批准了几种药物来治疗特定形式的肺癌和大肠癌。

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《Nature》 |2007年第7132期|p.112-113|共2页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Tumour-associated macrophages targeted transfection with NF-kappa B decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice [J] . Kono Yusuke, Kawakami Shigeru, Higuchi Yuriko, Journal of drug targeting . 2014,第1a10期

机译：肿瘤相关巨噬细胞靶向转染NF-κB诱饵/甘露糖修饰的泡沫脂质复合物抑制荷瘤小鼠的肿瘤生长
2. Comment on: Endogenous retroviruses expressed in human tumours cannot be used as targets for anti-tumour vaccines [J] . Amaia Vergara Bermejo, Karen N?rgaard Nielsen, Peter Johannes Holst Translational Oncology . 2021,第5期

机译：评论：人肿瘤中表达的内源性逆转录病毒不能用作抗肿瘤疫苗的靶标
3. Endogenous retroviruses expressed in human tumours cannot be used as targets for anti-tumour vaccines [J] . Joachim Denner Translational Oncology . 2021,第1期

机译：在人肿瘤中表达的内源性逆转录病毒不能用作抗肿瘤疫苗的靶标
4. Gene Therapy Targeted by Ionising Radiation Targets Both Tumour Cells and Tumour Vasculature [C] . Helena J. Mauceri, Michael A. Beckett, Saraswathy Seetharem, International congress of radiation research . 2000

机译：通过电离辐射靶向的基因治疗靶向肿瘤细胞和肿瘤脉管系统
5. The combi-targeting concept: A novel tumour targeting strategy. [D] . Matheson, Stephanie L. 2003

机译：组合靶向概念：一种新颖的肿瘤靶向策略。
6. Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8+ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes [O] . Laura Sanz-Ortega, Yadileiny Portilla, Sonia Pérez-Yagüe, 2019

机译：磁性靶向过继转移的装载有肿瘤特异性纳米粒子的CD8 + T细胞在癌症小鼠模型中不会改善其肿瘤浸润但会促进这些细胞在引流肿瘤的淋巴结中保留
7. Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature [O] . Adam Leach, Peter Smyth, Laura Ferguson, 2020

机译：抗DLL4 VNAR靶向纳米颗粒，用于靶向肿瘤和肿瘤相关脉管系统

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