Genetic test may lead to waste of healthy embryos

Roger Gosden

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Genetic test may lead to waste of healthy embryos

机译：基因测试可能会浪费健康的胚胎

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Your News Feature "The first cut" (Nature 445,479-480; 2007) highlights a controversy about preimplantation genetic diagnosis (PGD), a procedure to test for genetic disease that is now more widely used for screening chromosomes in embryos after in vitro fertilization (IVF). Randomized clinical trials are needed to determine whether aneuploidy screening improves pregnancy rates, or whether embryo biopsy has any impact on the health of future children and adults. There is less doubt, however, that PGD encourages the waste of healthy embryos. Your News Feature pointed out that this can potentially happen if mosaic embryos normalize in culture, but a significant fraction may occur from misdiagnosis.

机译：您的新闻特稿“首次切入”（自然445,479-480； 2007年）突出了有关植入前遗传学诊断（PGD）的争议，PGD是一种检测遗传病的方法，目前已被广泛用于体外受精后筛查胚胎中的染色体（ IVF）。需要进行随机临床试验以确定非整倍性筛查是否可以提高妊娠率，或者胚胎活检是否会对未来儿童和成人的健康产生影响。但是，毫无疑问，PGD鼓励浪费健康的胚胎。您的新闻特稿指出，如果花样胚在培养中正常化，则有可能发生这种情况，但很大一部分可能是由于误诊造成的。

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来源
《Nature》 |2007年第7134期|p.372|共1页
作者
Roger Gosden;
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作者单位

Weill Medical College, Cornell University, New York, New York 10021, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles [J] . Capalbo Antonio, Treff Nathan, Cimadomo Danilo, Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society . 2017,第6期

机译：异常受精的卵母细胞可能导致健康的活产出生物：改进的遗传技术用于遗传试验可用于拯救在体外施肥循环中的活胚胎
2. RNA single-cell sequencing could lead to eight-cell embryo genetic testing [J] . CoakerH., GrundyA. Bioanalysis . 2013,第19期

机译：RNA单细胞测序可导致八细胞胚胎基因检测
3. Is cell-free DNA in spent embryo culture medium an alternative to embryo biopsy for preimplantation genetic testing? A systematic review [J] . Reproductive biomedicine online . 2020,第6期

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5. Testing a model of healthy marriage/healthy relationships: The prediction of parenting and child well-being. [D] . Shambleau, Krista M. 2010

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6. Policy-Led Comparative Environmental Risk Assessment of Genetically Modified Crops: Testing for Increased Risk Rather Than Profiling Phenotypes Leads to Predictable and Transparent Decision-Making [O] . Alan Raybould, Phil Macdonald 2018

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7. Genetic test may lead to waste of healthy embryos [O] . Roger Gosden 2007

机译：遗传测试可能导致浪费健康的胚胎
8. Interim Report on the Genetic and Animal Toxicity Testing of SRC-I Products, Intermediates, and Waste Materials. Appendix C. Chemical Evaluation of SRC Samples for Genetic Toxicity Testing - Basic Program Reports [R] . Drozdowicz, B. Z., Kelly, C. M. 1983

机译：sRC-I产品，中间体和废料的遗传和动物毒性测试中期报告。附录C.用于遗传毒性测试的sRC样品的化学评估 - 基本程序报告

Genetic test may lead to waste of healthy embryos

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