TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Michaela U. Gack; Young C. Shin; Chul-Hyun Joo; Tomohiko Urano; Chengyu Liang; Lijun Sun; Osamu Takeuchi; Shizuo Akira; Zhijian Chen; Satoshi Inoue; Jae U. Jung

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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

机译：TRIM25环手指E3泛素连接酶对于RIG-I介导的抗病毒活性至关重要

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Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, which contain a cluster of a RING-finger domain, a B box/coiled-coil domain and a SPRY domain, are involved in various cellular processes, including cell proliferation and antiviral activity. Here we report that the amino-terminal caspase recruitment domains (CARDs) of RIG-I undergo robust ubiquitination induced by TRIM25 in mammalian cells.

机译：维甲酸诱导基因I（RIG-I;也称为DDX58）是一种胞质病毒RNA受体，可与MAVS（也称为VISA，IPS-1或Cardif）相互作用，以诱导I型干扰素介导的宿主针对先天性免疫保护病毒感染。此外，包含RING-指结构域，B box /螺旋结构域和SPRY结构域的簇的三方基序（TRIM）蛋白家族成员参与各种细胞过程，包括细胞增殖和抗病毒活性。。在这里我们报告说，RIG-1的氨基末端胱天蛋白酶募集结构域（CARDs）在哺乳动物细胞中经历了由TRIM25诱导的强健泛素化。

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来源
《Nature》 |2007年第7138期|p.916-920|共5页
作者
Michaela U. Gack; Young C. Shin; Chul-Hyun Joo; Tomohiko Urano; Chengyu Liang; Lijun Sun; Osamu Takeuchi; Shizuo Akira; Zhijian Chen; Satoshi Inoue; Jae U. Jung;
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作者单位

Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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5. Viral Hijacking of Host E3 Ubiquitin Ligase Machinery for the Degradation of Host Antiviral Factors. [D] . Wolfe, Leslie S. 2012

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6. The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings [O] . Dongqing Xu, Fang Lin, Yan Jiang, 2014

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7. Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity [O] . K. Kuniyoshi, O. Takeuchi, S. Pandey, 2014

机译：RNA结合E3泛素连接酶MEX3C在RIAR-I介导的抗病毒先天免疫力中的关键作用

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

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