Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins

Gerald W. Hart; Michael P. Housley; Chad Slawson

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Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins

机译：O-连接的β-N-乙酰氨基葡萄糖在细胞质蛋白上的循环

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All animals and plants dynamically attach and remove O-linked β-N-acetylglucosamine (O-GlcNAc) at serine and threonine residues on myriad nuclear and cytoplasmic proteins. O-GlcNAc cycling, which is tightly regulated by the concerted actions of two highly conserved enzymes, serves as a nutrient and stress sensor. On some proteins, O-GlcNAc competes directly with phosphate for serine/threonine residues. Glycosylation with O-GlcNAc modulates signalling, and influences protein expression, degradation and trafficking. Emerging data indicate that O-GlcNAc glycosylation has a role in the aetiology of diabetes and neurodegeneration.

机译：所有动植物都会动态地附着并去除无数核蛋白和胞质蛋白上丝氨酸和苏氨酸残基上的O-连接的β-N-乙酰氨基葡萄糖（O-GlcNAc）。 O-GlcNAc循环受两种高度保守的酶的协同作用严格调节，可作为营养和压力传感器。在某些蛋白质上，O-GlcNAc与磷酸盐直接竞争丝氨酸/苏氨酸残基。 O-GlcNAc的糖基化调节信号传导，并影响蛋白质表达，降解和运输。新兴数据表明，O-GlcNAc糖基化在糖尿病和神经退行性疾病的病因中具有作用。

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来源
《Nature》 |2007年第7139期|p.1017-1022|共6页
作者
Gerald W. Hart; Michael P. Housley; Chad Slawson;
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作者单位

Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205-2185, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Nucleocytoplasmic Glycosylation, O-linked β-N-Acetylglucosamine [J] . N.E. Zachara, W.D. Cheung, G.W. Hart Current organic chemistry . 2004,第5期

机译：核质糖基化，O-连接的β-N-乙酰氨基葡萄糖
2. Nucleocytoplasmic Glycosylation, O-linked β-N-Acetylglucosamine [J] . N. E. Zachara W. D. Cheung G. W. Hart Current Organic Chemistry . 2004,第5期

机译：核质糖基化，O-连接的β-N-乙酰氨基葡萄糖
3. O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma [J] . Zhe Qiao, Chengxue Dang, Bin Zhou, 生物医学研究杂志（英文版） . 2012,第004期

机译：O-连接的N-乙酰氨基葡萄糖转移酶（OGT）在食管鳞状细胞癌中过表达并促进O-连接的蛋白糖基化
4. GLOBAL-SCALE ANALYSIS OF PROTEIN NUCLEOCYTOPLASMIC TRAFFICKING IN RAT HEPATOCYTES AFTER ETHANOL EXPOSURE [C] . Shikha Mahajan, Crystina L. Kriss, Stanley M. Stevens ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：乙醇暴露后大鼠肝细胞蛋白质核细胞胞质贩运的全球规模分析
5. Regulation and function of O-linked N-acetylglucosamine modification of proteins with glucose deprivation. [D] . Taylor, Rodrick Paul. 2008

机译：葡萄糖剥夺蛋白的O-连接N-乙酰氨基葡糖修饰的调节和功能。
6. Hsp90 regulates O-linked β-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked β-N-acetylglucosamine modification in endothelial cells [O] . Fengxue Zhang, Connie M. Snead, John D. Catravas -1

机译：Hsp90调节O-连接的β-N-乙酰氨基葡萄糖转移酶：调节内皮细胞中蛋白质O-连接的β-N-乙酰氨基葡萄糖修饰的新机制
7. Identification of O-Linked N-Acetylglucosamine (O-GlcNAc)-modified Osteoblast Proteins by Electron Transfer Dissociation Tandem Mass Spectrometry Reveals Proteins Critical for Bone Formation [O] . Alexis K. Nagel, Michael Schilling, Susana Comte-Walters, 2013

机译：通过电子转移离解串联质谱法鉴定O-连接的N-乙酰葡糖胺（O-GLCNAC）制定的成骨细胞蛋白揭示了骨形成关键的蛋白质

Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins

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