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Oxidative damage has been linked to ageing and neurodegenerative disease for decades, but the physiological link between oxidation and the genetics of ageing remains elusive. Now it may have been found. Huntingtons and several other neurodegenerative diseases involve the expansion of CAG triplet repeats. In a mouse model of human Huntingtons disease, this expansion occurs in mid-life and continues throughout life. The expansion occurs in terminally differentiated cells and is associated with oxidative damage.

机译：氧化损伤与衰老和神经退行性疾病有数十年的联系，但是氧化与衰老遗传之间的生理联系仍然难以捉摸。现在可能已经找到。亨廷顿氏病和其他几种神经退行性疾病涉及CAG三联体重复序列的扩展。在人类亨廷顿氏病的小鼠模型中，这种扩增发生在中年，并持续一生。扩增发生在终末分化的细胞中，并与氧化损伤有关。

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《Nature》 |2007年第7143期|p.xixxxi|共2页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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