How a T cell sees sugar

D. Branch Moody

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How a T cell sees sugar

机译：T细胞如何看到糖

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T cells of the immune system recognize lipids, as well as peptides, extending our ideas about such target antigens. A crystal structure of a T-cell receptor docked to antigen shows how a sugar controls lipid recognition. Most cellular receptors coevolve with their target ligands through repeated interactions over millennia. The immune system has no such luxury. When new infectious agents such as HIV or avian influenza strike a population, immune receptors must reliably respond to foreign molecules - known as antigens - on their first encounter.

机译：免疫系统的T细胞识别脂质以及肽，从而扩展了我们对此类靶抗原的认识。紧靠抗原的T细胞受体的晶体结构显示了糖如何控制脂质识别。几千年来，大多数细胞受体通过重复相互作用与其靶配体一起进化。免疫系统没有这种奢侈。当诸如艾滋病毒或禽流感的新型传染性病原体侵袭时，免疫受体在初次接触时必须可靠地对称为抗原的外来分子作出反应。

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来源
《Nature》 |2007年第7149期|36-37|共2页
作者
D. Branch Moody;
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作者单位

Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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How a T cell sees sugar

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