Unravelling the pathogenesis of inflammatory bowel disease

R. J. Xavier; D. K. Podolsky

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Unravelling the pathogenesis of inflammatory bowel disease

机译：阐明炎症性肠病的发病机理

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Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors implicate commensal bacteria (or their products), rather than conventional pathogens, as drivers of dysregulated immunity and IBD. Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD.

机译：最近，由于三个相关的研究方向，在对炎症性肠病（IBD）的分子发病机理的理解上取得了实质性进展。首先，已发现IBD是发现易感基因的最复杂的复杂疾病，并且这些都表明了上皮屏障功能以及先天性和适应性免疫在疾病发病机理中的重要性。其次，旨在确定环境因素的努力将共生细菌（或其产物）而不是常规病原体作为免疫功能和IBD失调的驱动因素。第三，鼠模型表现出溃疡性结肠炎的许多特征并且似乎是细菌驱动的，已经帮助阐明了IBD的发病机理/黏膜免疫病理学。

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来源
《Nature》 |2007年第7152期|427-434|共8页
作者
R. J. Xavier; D. K. Podolsky;
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作者单位

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Harvard Medical School, Boston, Massachusetts 02114, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Unravelling the pathogenesis of inflammatory bowel disease

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