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Differential parasite drive

机译:差分寄生驱动

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摘要

Our knowledge of the inner workings of malaria parasites comes largely from lab-based studies. But parasites growing in humans may have greater metabolic flexibility than those growing in Petri dishes. Malaria parasites kill more than a million people every year. These minuscule organisms, belonging to the genus Plasmodium, ensconce themselves inside our red blood cells. They eat our oxygen-carrying haemoglobin protein, and sup on the rich supply of glucose in our blood plasma. Hidden from our immune system within our own cells, they multiply exponentially, inducing anaemia, acidity of the blood, low blood sugar, fluid build-up in the lungs, seizures and blockage of brain capillaries — complications that can kill a person within ten days of being infected by a malaria-carrying mosquito. Until now, we believed that malaria parasites burned the glucose they stole from our plasma using a simple and relatively inefficient process known as glyco-lysis. After all, why would a parasite bother to extract maximum energy from glucose when abundant free glucose is at hand?
机译:我们对疟原虫内部运作的了解主要来自基于实验室的研究。但是,人类生长的寄生虫可能比培养皿中生长的寄生虫具有更大的代谢灵活性。疟疾寄生虫每年杀死超过一百万人。这些微小的生物属于疟原虫属,将自身包裹在我们的红细胞中。他们吃了我们携带氧气的血红蛋白,并补充了我们血浆中葡萄糖的丰富供应。它们被隐藏在自身细胞内的免疫系统中,呈指数增长,从而引起贫血,血液酸度,低血糖,肺部积液,癫痫和脑毛细血管阻塞-并发症会在十天内杀死一个人感染了携带疟疾的蚊子。到目前为止,我们认为疟疾寄生虫使用一种称为糖酵解的简单且效率相对较低的过程来燃烧从血浆中偷走的葡萄糖。毕竟,当手头有大量游离葡萄糖时,为什么寄生虫会费力从葡萄糖中提取最大能量?

著录项

  • 来源
    《Nature》 |2007年第7172期|955-956|共2页
  • 作者单位

    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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