PROTEINS TO PROTEOMES

Tanguy Chouard; Joshua Finkelstein

首页> 外文期刊>Nature >PROTEINS TO PROTEOMES

【24h】

PROTEINS TO PROTEOMES

机译：蛋白质组学

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

How are innumerable protein functions integrated so that a living cell interacts coherently with its environment? This question is central to an emerging science of biological information processing — systems biology. For nearly two centuries, 'physiological chemists' had to tackle the opposite problem: making sense of the murky 'protoplasm' of cells by dividing it into separate components. From the discovery in 1840 of haemoglobin crystals in earthworm blood spread on glass plates, to the development of the ultracentrifuge in the 1920s, to contemporary genomics research, biochemists have strived to study life's parts in isolation. Now that part lists are almost complete, the pieces must be brought back together.

机译：如何整合无数的蛋白质功能，以使活细胞与其周围环境协调一致地相互作用？这个问题对于新兴的生物信息处理科学-系统生物学至关重要。在近两个世纪的时间里，“生理化学家”不得不解决相反的问题：通过将细胞分成多个单独的部分来理解模糊的细胞“原生质”。从1840年发现worm血液在玻璃板上散布的血红蛋白晶体，到1920年代超速离心机的发展，再到当代基因组学研究，生物化学家都致力于分离研究生命的各个部分。现在零件清单已基本完成，必须将零件放在一起。

著录项

来源
《Nature》 |2007年第7172期|p.963|共1页
作者
Tanguy Chouard; Joshua Finkelstein;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. The Human Dental Pulp Proteome and N-Terminome: Levering the Unexplored Potential of Semitryptic Peptides Enriched by TAILS to Identify Missing Proteins in the Human Proteome Project in Underexplored Tissues [J] . Eckhard Ulrich, Marino Giada, Abbey Simon R., Journal of proteome research . 2015,第9期

机译：人类牙髓蛋白质组和N末端组：利用TAILS丰富的半胰蛋白酶肽的未开发潜力来确定人类蛋白质组项目中未开发组织中的缺失蛋白
2. THE HDL PROTEOME - CHALLENGES TO ANALYSING HDL-ASSOCIATED PROTEINS AND DISENTANGLING ASSOCIATED PROTEINS FROM CONTAMINATING PROTEINS [J] . Curley S., Dillon E., Byrne R., Atherosclerosis . 2019,第期

机译：HDL蛋白质组 - 分析HDL相关蛋白质和解解蛋白质的挑战蛋白质的挑战
3. A Molecular Rotor-Based Halo-Tag Ligand Enables a Fluorogenic Proteome Stress Sensor to Detect Protein Misfolding in Mildly Stressed Proteome [J] . Fares Matthew, Li Yinghao, Liu Yu, Bioconjugate Chemistry . 2018,第1期

机译：基于分子转子的卤素标签配体使荧光蛋白质组应力传感器能够检测轻度胁迫蛋白质组中的蛋白质误用
4. CSF proteome characterization Dynamics of plasma proteins and CNS specific proteins in CSF [C] . Jill A. Opsahl, Elise Aasebo, Yngvild Bjorlykke, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：CSF中血浆蛋白质蛋白质和CNS特异性蛋白质的CSF蛋白质组特征动态
5. The analysis of proteins and peptides by mass spectrometry: From the whole cell proteome to small protein complexes. [D] . High, Anthony Andrew. 2003

机译：通过质谱分析蛋白质和多肽：从整个细胞蛋白质组到小型蛋白质复合物。
6. In-Depth Analysis of the Thylakoid Membrane Proteome of Arabidopsis thaliana Chloroplasts: New Proteins New Functions and a Plastid Proteome Database [O] . Giulia Friso, Lisa Giacomelli, A. Jimmy Ytterberg, 2004

机译：拟南芥叶绿体类囊体膜蛋白质组的深入分析：新蛋白质新功能和质体蛋白质组数据库
7. Profiling protein expression in C. elegans Metabolic monitoring of liver transplants Isolating phosphopeptides with a dendrimer Proteome of Trypanosoma cruzi New protein immobilization technique Early detection of ovarian cancer Protein isoforms in serum vs. plasma Protein losses in 2DE Pituitary gland proteome [O] . 2005

机译：C. elegans的谱分析蛋白表达肝移植的代谢监测用树枝状聚合物分离磷酸肽胰蛋白酶瘤Cruzi的蛋白质组新蛋白质固定技术早期检测卵巢癌血清蛋白质同种型与血浆 2DE中的蛋白质损失垂体腺蛋白质组

PROTEINS TO PROTEOMES

摘要

著录项

相似文献

相关主题

期刊订阅