hERG potassium channels and cardiac arrhythmia.

Sanguinetti MC; Tristani Firouzi M

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hERG potassium channels and cardiac arrhythmia.

机译：hERG钾通道和心律不齐。

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摘要

hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias. Arrhythmia can also be induced by a blockage of hERG channels by a surprisingly diverse group of drugs. This side effect is a common reason for drug failure in preclinical safety trials. Insights gained from the crystal structures of other potassium channels have helped our understanding of the block of hERG channels and the mechanisms of gating.

机译：hERG钾通道对于心脏的正常电活动至关重要。 HERG基因的遗传突变会导致长期QT综合征，这种疾病使个体易患危及生命的心律失常。心律失常还可以通过令人惊讶的多种药物阻断hERG通道来诱发。这种副作用是临床前安全性试验中药物失败的常见原因。从其他钾通道的晶体结构获得的见解有助于我们了解hERG通道的阻滞和门控机制。

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来源
《Nature》 |2006年第7083期|P.463-469|共7页
作者
Sanguinetti MC; Tristani Firouzi M;
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作者单位

Department of Physiology, University of Utah, 95 South 2000 East, Salt Lake City, Utah 84112, USA. sanguinetti@cvrti.utah.edu;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Potassium Channels; Arrhythmia; Personal failure; Comprehension; 钾通道; 心律失常;

机译：Potassium Channels;Arrhythmia;Personal failure;Comprehension;钾通道;心律失常;

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专利

1. Teratogenicity by the hERG potassium channel blocking drug almokalant: use of hypoxia marker gives evidence for a hypoxia-related mechanism mediated via embryonic arrhythmia. [J] . Danielsson BR, Skold AC, Johansson A, Toxicology and Applied Pharmacology . 2003,第2期

机译：hERG钾通道阻断药物almokalant的致畸性：使用缺氧标记物为通过胚胎心律不齐介导的缺氧相关机制提供了证据。
2. Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia. [J] . Nicole Schmitt, Morten Grunnet, S?ren-Peter Olesen Physiological Reviews . 2014,第2期

机译：心脏钾通道亚型：在复极化和心律不齐中的新作用。
3. Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia. [J] . Nicole Schmitt, Morten Grunnet, S?ren-Peter Olesen Physiological Reviews . 2014,第2期

机译：心脏钾通道亚型：倒容性和心律失常的新作用。
4. Structural determinants for high-affinity block of hERG potassium channels [C] . John Mitcheson, Matthew Perry, Phillip Stansfeld, symposium on The hERG cardiac potassium channel: structure, function, and long QT syndrome . 2005

机译：HERG钾通道高亲和力块的结构决定因子
5. Characterization of the hERG potassium channels channel activation gate region. [D] . Wynia Smith, Sarah L. 2009

机译：hERG钾离子通道通道激活门区域的表征。
6. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. [O] . M C Sanguinetti, M E Curran, P S Spector, 1996

机译：遗传性心律失常中HERG K +通道功能障碍的频谱。
7. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. [O] . Sanguinetti, M C, Curran, M E, Spector, P S, 1996

机译：遗传性心律失常中HERG K +通道功能障碍的频谱。

hERG potassium channels and cardiac arrhythmia.

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