Manel Esteller s phone did not stop ringing for weeks. It was summer 2005, and he and his team at the Spanish National Cancer Centre in Madrid had just published a study comparing the activity of DNA in identical twins. The anxious callers were invariably twins whose sibling had developed a serious disease such as cancer or diabetes. Could the study help predict whether they too would succumb, they asked. Did the identical DNA sequence they shared with their afflicted twin mean they had the same genetic predisposition to illness?
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