How does a painkiller harm the heart?

Meredith Wadman

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How does a painkiller harm the heart?

机译：止痛药如何伤害心脏？

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It was Garret FitzGerald, the chair of pharmacology at the University of Pennsylvania, who first proposed that the painkiller Vioxx and its cousins might cause heart attacks by tipping a crucial hormonal balance. So neither of two attention-grabbing data sets published this month has come as a great surprise to him, despite the implications the data are likely to have for the 11,500 lawsuits from former patients that dog the drug's manufacturer, Merck.

机译：宾夕法尼亚大学药理学系主任加勒特·菲茨杰拉德（Garret FitzGerald）首先提出止痛药Vioxx及其表亲可能通过破坏至关重要的荷尔蒙平衡而引起心脏病发作。因此，尽管这个数据可能会对从前制造商默克公司的11,500例诉讼产生影响，但本月发布的两个引人注目的数据集都没有给他一个大惊喜。

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《Nature》 |2006年第7091期|p.262|共1页
作者
Meredith Wadman;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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2. A Fine Line: Painkillers and Pleasure in the Age of Anxiety , Dertadian G. C. Singapore : Palgrave Macmillan ; 2019 , ISBN: 9789811347139 . A Fine Line: Painkillers and Pleasure in the Age of Anxiety A Fine Line: Painkillers and Pleasure in the Age of Anxiety , Dertadian G. C. Dertadian Dertadian G. C. G. C. Singapore Singapore : Palgrave Macmillan Palgrave Macmillan ; 2019 2019 , ISBN: 9789811347139 9789811347139 . [J] . Hulme Shann Addiction . 2020,第7期

机译：一条细线：焦虑时代的止痛药和乐趣，Dertadian G. C.新加坡：Palgrave Macmillan; 2019年，ISBN：9789811347139 一条细线：痛苦和焦虑时代的乐趣焦虑：止痛药和焦虑时代的乐趣，Dertadian G. C. Dertadian Dertadian G. C. G.C. Singapore Singapore：Palgrave Macmillan Palgrave Macmillan; 2019年2019年，ISBN：9789811347139 9789811347139
3. Letter by Scott and Haykowsky Regarding Articles, "Can Intensive Exercise Harm the Heart? The Benefits of Competitive Endurance Training for Cardiovascular Structure and Function" and "Can Intensive Exercise Harm the Heart? You Can Get Too Much of a Good Thing" [J] . Scott Jessica M., Haykowsky Mark J. Circulation: An Official Journal of the American Heart Association . 2015,第23期

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4. PerViz: Painkillers for pervasive application debugging [C] . Pham Hubert, Mazzola Paluska Justin 2010 IEEE International Conference on Pervasive Computing and Communications (PerCom 2010) . 2010

机译：PerViz：用于广泛应用程序调试的止痛药
5. Problematic Painkiller Use in the General Population: A Multi-National Comparison Exploring the Role of Accessibility of Painkillers and Psychological Factors [D] . Said, Omimah. 2017

机译：有问题的止痛药在一般人群中使用：多国比较探讨止痛药和心理因素可达性的作用
6. Moderate use of painkillers presents no harm to kidneys [O] . Deborah Josefson 2001

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7. Prescription painkiller misuse and the perceived risk of harm from using heroin [O] . Shashi N. Kapadia, Yuhua Bao 2019

机译：处方止痛药滥用和使用海洛因的伤害的风险
8. Adding ACRIs and/or ARBs to Standard Therapy for Stable Ischemic Heart Disease: Benefits and Harms. Clinician Guide. [R] . 2010

机译：将aCRI和/或aRB添加到稳定性缺血性心脏病的标准疗法中：益处和危害。临床医师指南。

How does a painkiller harm the heart?

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