• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Soma-germline interactions coordinate homeostasis and growth in the Drosophila gonad.
【24h】

Soma-germline interactions coordinate homeostasis and growth in the Drosophila gonad.

机译：果蝇生殖腺中的索玛-种系相互作用调节体内稳态和生长。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The ability of organs such as the liver or the lymphoid system to maintain their original size or regain it after injury is well documented. However, little is known about how these organs sense that equilibrium is breached, and how they cease changing when homeostasis is reached. Similarly, it remains unclear how, during normal development, different cell types within an organ coordinate their growth. Here we show that during gonad development in the fruitfly Drosophila melanogaster the proliferation of primordial germ cells (PGCs) and survival of the somatic intermingled cells (ICs) that contact them are coordinated by means of a feedback mechanism composed of a positive signal and a negative signal. PGCs express the EGF receptor (EGFR) ligand Spitz, which is required for IC survival. In turn, ICs inhibit PGC proliferation. Thus, homeostasis and coordination of growth between soma and germ line in the larval ovary is achieved by using a sensor of PGC numbers (EGFR-mediated survival of ICs) coupled toa correction mechanism inhibiting PGC proliferation. This feedback loop ensures that sufficient numbers of PGCs exist to fill all the stem-cell niches that form at the end of larval development. We propose that similar feedback mechanisms might be generally used for coordinated growth, regeneration and homeostasis.
机译：肝脏或淋巴系统等器官在受伤后保持其原始大小或恢复原始大小的能力已得到充分证明。然而，对于这些器官如何感觉到平衡被破坏以及达到稳态后它们如何停止变化的了解甚少。同样，尚不清楚在正常发育过程中，器官内不同细胞类型如何协调其生长。在这里，我们显示在果蝇果蝇的性腺发育过程中，原始生殖细胞（PGCs）的增殖和与它们接触的体细胞混合细胞（ICs）的生存是通过由正信号和负信号组成的反馈机制来协调的信号。 PGC表达EGF受体（EGFR）配体Spitz，这是IC生存所必需的。反过来，IC抑制PGC增殖。因此，通过使用PGC数传感器（EGFR介导的IC存活率）与抑制PGC增殖的校正机制耦合，可以实现幼虫卵巢中体细胞与种系之间的动态平衡和生长协调。该反馈回路可确保存在足够数量的PGC，以填补幼虫发育结束时形成的所有干细胞壁ni。我们建议类似的反馈机制通常可用于协调的生长，再生和体内平衡。

著录项

  • 来源
    《Nature》 |2006年第7107期|P.97-100|共4页
  • 作者

    Gilboa L; Lehmann R;

  • 作者单位

    Howard Hughes Medical Institute and Developmental Genetics Program, The Skirball Institute and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 基础医学;
  • 关键词

    growth aspects; Homeostasis; development aspects; survival aspects; Gonads; 体内稳态; 性腺;

    机译：growth aspects;Homeostasis;development aspects;survival aspects;Gonads;体内稳态;性腺;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号