A century-old debate on protein aggregation and neurodegeneration enters the clinic.

Lansbury PT; Lashuel HA

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A century-old debate on protein aggregation and neurodegeneration enters the clinic.

机译：关于蛋白质聚集和神经变性的百年争论进入了临床。

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The correlation between neurodegenerative disease and protein aggregation in the brain has long been recognized, but a causal relationship has not been unequivocally established, in part because a discrete pathogenic aggregate has not been identified. The complexity of these diseases and the dynamic nature of protein aggregation mean that, despite progress towards understanding aggregation, its relationship to disease is difficult to determine in the laboratory. Nevertheless, drug candidates that inhibit aggregation are now being tested in the clinic. These have the potential to slow the progression of Alzheimer's disease, Parkinson's disease and related disorders and could, if administered presymptomatically, drastically reduce the incidence of these diseases. The clinical trials could also settle the century-old debate about causality.

机译：长期以来，人们已经认识到神经退行性疾病与大脑中蛋白质聚集之间的相关性，但尚未明确建立因果关系，部分原因是尚未确定离散的致病性聚集体。这些疾病的复杂性和蛋白质聚集的动态性质意味着，尽管在理解聚集方面取得了进展，但仍难以在实验室中确定其与疾病的关系。尽管如此，目前正在临床上测试抑制聚集的候选药物。这些具有减缓阿尔茨海默氏病，帕金森氏病和相关疾病的进展的潜力，并且如果有症状地给予，可能会大大降低这些疾病的发生率。临床试验也可以解决百年以来因果关系的争论。

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来源
《Nature》 |2006年第7113期|P.774-779|共6页
作者
Lansbury PT; Lashuel HA;
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作者单位

Department of Neurology, Harvard Medical School and Brigham and Women's Hospital, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA. lansbury@rics.bwh.harvard.edu;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Proteins; Clinic; Nerve Degeneration; Progression; 蛋白质类; 神经变性;

机译：Proteins;Clinic;Nerve Degeneration;Progression;蛋白质类;神经变性;

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1. Reaping what you sow: Cross-seeding between aggregation-prone proteins in neurodegeneration. [J] . Talene A Yacoubian, David G Standaert Movement disorders . 2014,第3期

机译：收获：在神经退行性病变中易于聚集的蛋白质之间进行交叉播种。
2. Reaping what you sow: Cross-seeding between aggregation-prone proteins in neurodegeneration. [J] . Talene A Yacoubian, David G Standaert Movement disorders . 2014,第3期

机译：收获你播种的内容：神经变性中聚集在易患蛋白质之间的跨越。
3. Equine grass sickness, but not botulism, causes autonomic and enteric neurodegeneration and increases soluble N-ethylmaleimide-sensitive factor attachment receptor protein expression within neuronal perikarya [J] . McGorum B. C., Scholes S., Milne E. M., Equine Veterinary Journal . 2016,第6期

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4. Overexpression of human amyloid precursor protein causes neurodegeneration and loss of synaptic proteins in transgenic Drosophila [C] . Sarantseva S., Bolshakova O., Timoshenko S., International Conference on Alzheimer's and Parkinson's Diseases . 2009

机译：人淀粉样蛋白前体蛋白的过度表达导致转基因果蝇中的神经变性和突触蛋白的丧失
5. Inferring Aggregation Mechanisms of Molecules Involved in Neurodegeneration through Quantitative Studies of Phase Behavior [D] . Crick, Scott L. 2011

机译：通过相行为的定量研究推断参与神经变性的分子的聚集机制
6. Rationalizing the Role of Monosodium Glutamate in the Protein Aggregation Through Biophysical Approaches: Potential Impact on Neurodegeneration [O] . Ishfaq Ahmad Ahanger, Sania Bashir, Zahoor Ahmad Parray, 2021

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7. Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles [O] . Kathryn A. Jewett, Ruth E. Thomas, Chi Q. Phan, 2020

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A century-old debate on protein aggregation and neurodegeneration enters the clinic.

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