Enzyme target to latch on to

Malcolm A. Leissring; Dennis J. Selkoe

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Enzyme target to latch on to

机译：锁定酶的目标

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Insulin-degrading enzyme is implicated in diabetes and Alzheimer's disease, but few molecular tools exist that can probe its function. A study now reveals its unusual structure and may lead to an expanded toolbox. Proteases are vital enzymes that havebeen targeted for the treatment of many diseases. One such protease, insulin-degrading enzyme (IDE), has strong links to diabetes and Alzheimer's disease but has nonetheless proved to be an elusive drug target, despite more than 50 years of intensive research. On page 870 of this issue, Shen and colleagues' reveal high-resolution crystal structures of IDE that open the door to the rational design of pharmacological modulators of this protease*. Crucially, the authors show that it might be possible to develop not just inhibitors, but activators as well.

机译：胰岛素降解酶与糖尿病和阿尔茨海默氏病有关，但是很少有分子工具可以探测其功能。现在的一项研究揭示了其异常的结构，并可能导致工具箱的扩展。蛋白酶是重要的酶，已被用于治疗多种疾病。一种这样的蛋白酶，即胰岛素降解酶（IDE），与糖尿病和阿尔茨海默氏病有很强的联系，尽管有50多年的深入研究，但事实证明它仍是一种难以捉摸的药物。在本期杂志的第870页上，Shen和他的同事揭示了IDE的高分辨率晶体结构，为该蛋白酶药理调节剂的合理设计打开了大门。至关重要的是，作者们表明，不仅可能开发抑制剂，而且可能开发活化剂。

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《Nature》 |2006年第7113期|p.761-762|共2页
作者
Malcolm A. Leissring; Dennis J. Selkoe;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Enzyme target to latch on to

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