Analysis of one million base pairs of Neanderthal DNA

Green RE; Krause J; Ptak SE; Briggs AW; Ronan MT; Simons JF; Du L; Egholm M; Rothberg JM; Paunovic M

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Analysis of one million base pairs of Neanderthal DNA

机译：分析一百万个尼安德特人DNA碱基对

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Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes specific to anatomically fully modern humans. We have identified a 38,000- year- old Neanderthal fossil that is exceptionally free of contamination from modern human DNA. Direct high- throughput sequencing of a DNA extract from this fossil has thus far yielded over one million base pairs of hominoid nuclear DNA sequences. Comparison with the human and chimpanzee genomes reveals that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago. Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome- sequencing effort.

机译：尼安德特人是与当代人类关系最密切的灭绝的原始人群体，因此尼安德特人的基因组提供了独特的机会来鉴定解剖学上完全现代的人类特有的遗传变化。我们已经鉴定出了38,000年的尼安德特人化石，其异常不含现代人类DNA的污染。迄今为止，直接从该化石中提取DNA的高通量测序已产生了超过一百万个碱基的类人核DNA序列。与人类和黑猩猩基因组的比较表明，现代人类和尼安德特人的DNA序列平均距今约500,000年前。现在，现有的技术和化石资源足以启动尼安德特人的基因组测序工作。

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来源
《Nature》 |2006年第7117期|p. 330-336|共7页
作者
Green RE; Krause J; Ptak SE; Briggs AW; Ronan MT; Simons JF; Du L; Egholm M; Rothberg JM; Paunovic M;
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作者单位

Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany;

454 Life Sci, Branford, CT 06405 USA;

Croatian Acad Sci & Arts, Inst Quaternary Paleontol & Geol, HR-10000 Zagreb, Croatia;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
ANCESTRAL POPULATION SIZES; MODERN HUMAN ORIGINS; ANCIENT DNA; HUMAN GENOME; ENZYMATIC AMPLIFICATION; MITOCHONDRIAL GENOME; DIVERGENCE TIMES; MTDNA SEQUENCE; DIVERSITY; HUMANS;

机译：祖先人口规模;现代人类起源;古DNA;人类基因组;酶促扩增;线粒体基因组;发散时间;MTDNA序列;多样性;人类;

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机译：对100万碱基对尼安德特人DNa的分析

Analysis of one million base pairs of Neanderthal DNA

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