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Chance caught on the wingcis-regulatory evolution and the origin of pigment patterns in Drosophila

机译：果蝇中机翼调控进化和色素图案起源的机会

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摘要

The gain, loss or modification of morphological traits is generally associated with changes in gene regulation during development. However, the molecular bases underlying these evolutionary changes have remained elusive. Here we identify one of the molecular mechanisms that contributes to the evolutionary gain of a male-specific wing pigmentation spot in Drosophila biarmipes, a species closely related to Drosophila melanogaster. We show that the evolution of this spot involved modifications of an ancestral cis-regulatory element of the yellow pigmentation gene. This element has gained multiple binding sites for transcription factors that are deeply conserved components of the regulatory landscape controlling wing development, including the selector protein Engrailed. The evolutionary stability of components of regulatory landscapes, which can be co-opted by chance mutations in cis-regulatory elements, might explain the repeated evolution of similar morphological patterns, such as wing pigmentation patterns in flies.
机译：形态特征的获得，丧失或修饰通常与发育过程中基因调控的变化有关。然而，这些进化变化的分子基础仍然难以捉摸。在这里，我们确定了一种果蝇双臂果蝇（Drosophila biarmipes）（一种与果蝇黑腹果蝇密切相关的物种）的雄性特定翼色素沉着斑的进化增益的分子机制之一。我们显示该点的演变涉及黄色色素沉着基因的祖先顺式调节元件的修饰。该元件已经获得了转录因子的多个结合位点，这些转录因子是控制机翼发育的调控景观（包括选择蛋白Engrailed）的高度保守组成部分。可以通过顺式调控元件的偶然突变来选择的调控景观组成部分的进化稳定性，可以解释类似形态模式（例如果蝇中的翅膀色素沉着模式）的重复进化。

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