Treatment of severe autoimmune disease by stem-cell transplantation

Sykes M; Nikolic B

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Treatment of severe autoimmune disease by stem-cell transplantation

机译：干细胞移植治疗严重的自身免疫性疾病

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Transplantation of haematopoietic stem cells - cells capable of self renewing and reconstituting all types of blood cell - can treat numerous lethal diseases, including leukaemias and lymphomas. It may now be applicable for the treatment of severe autoimmune diseases, such as therapy-resistant rheumatoid arthritis and multiple sclerosis. Studies in animal models show that the transfer of haematopoietic stem cells can reverse autoimmunity, and several mechanistic pathways may explain this phenomenon. The outcome of ongoing clinical trials, as well as of studies in patients and animal models, will help to determine the role that stem-cell transplantation can play in the treatment of autoimmune diseases.

机译：造血干细胞（能够自我更新和重构所有类型血细胞的细胞）的移植可以治疗多种致死性疾病，包括白血病和淋巴瘤。现在，它可用于治疗严重的自身免疫性疾病，例如对类风湿性关节炎和多发性硬化症具有治疗抵抗力的疾病。在动物模型中的研究表明，造血干细胞的转移可以逆转自身免疫，一些机制途径可以解释这种现象。正在进行的临床试验以及患者和动物模型研究的结果将有助于确定干细胞移植在自身免疫性疾病治疗中的作用。

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来源
《Nature》 |2005年第7042期|p. 620-627|共8页
作者
Sykes M; Nikolic B;
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作者单位

Harvard Univ, Massachusetts Gen Hosp, Sch Med,Bone Marrow Transplantat Sect, Transplantat Biol Res Ctr, Boston, MA 02129 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; REGULATORY T-CELLS; MIXED HEMATOPOIETIC CHIMERISM; TYPE-1 DIABETES-MELLITUS; STAGE RENAL-DISEASE; ALLOGRAFT TOLERANCE; LYMPHOHEMATOPOIETIC CHIMERISM; RHEUMATOID-ARTHRITIS; MULTIPLE-MYELOMA;

机译：骨髓移植;抗宿主病;调节性T细胞;混合造血嵌合体;1型糖尿病;阶段性肾脏疾病;同种异体移植耐受性;淋巴造血嵌合体;类风湿性关节炎;

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专利

1. Long-term immune reconstitution after autologous stem-cell transplantation for severe autoimmune diseases [J] . T Alexander, G Massenkeil, E Gromnica-Ihle, Arthritis Research . 2005,第Suppla1期

机译：自体干细胞移植后重度自身免疫疾病的长期免疫重建
2. Immune ablation and stem-cell therapy in autoimmune disease: Experimental basis for autologous stem-cell transplantation [J] . Dirk W van Bekkum Arthritis Research . 2000,第4期

机译：自身免疫性疾病的免疫消融和干细胞治疗：自体干细胞移植的实验基础
3. Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation [J] . Jacob M van Laar Arthritis Research . 2000,第4期

机译：自身免疫性疾病中的免疫消融和干细胞疗法：大剂量免疫抑制和造血干细胞移植后的免疫重建
4. Intense immunosuppression and stem cell transplantation in severe autoimmune diseases [C] . Lisukov, I.A. . 2000

机译：严重自身免疫疾病中的强免疫抑制和干细胞移植
5. Development of Immunosupressant and Peptide Loaded Microparticles as Tolerogenic Vaccines for Treatment of Autoimmune Diseases [D] . Kanthamneni, Naveen 2012

机译：免疫抑制剂和多肽微粒作为用于自身免疫性疾病的致耐受性疫苗的开发
6. Long-term immune reconstitution after autologous stem-cell transplantation for severe autoimmune diseases [O] . T Alexander, G Massenkeil, E Gromnica-Ihle, 2005

机译：自体干细胞移植后重度自身免疫疾病的长期免疫重建
7. Intense Immunosuppression and Stem-Cell Transplantation for Patients with Severe Rheumatic Autoimmune Disease: A Review [O] . Jacob M. Van Laar, Alan Tyndall 2003

机译：严重风湿自身免疫疾病患者的强烈免疫抑制和干细胞移植：综述

Treatment of severe autoimmune disease by stem-cell transplantation

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