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Regulation of immunity by self-reactive T cells

机译:自我反应性T细胞对免疫力的调节

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A basic principle of immunology is that lymphocytes respond to foreign antigens but tolerate self tissues. For developing T cells, the ability to distinguish self from non-self is acquired in the thymus, where the majority of self-reactive cells are eliminated. Recently, however, it has become apparent that some self-reactive T cells avoid being destroyed and instead differentiate into specialized regulatory cells. This appears to be beneficial. Subpopulations of self-reactive T cells have a strong influence on self tolerance and may represent targets for therapeutic intervention to control a variety of autoimmune diseases, tumour growth and infection.
机译:免疫学的基本原理是淋巴细胞对外来抗原有反应,但能耐受自身组织。对于发育中的T细胞,在胸腺中获得了将自身与非自身区分开的能力,而胸腺则消除了大多数自我反应性细胞。然而,近来已经变得明显的是,一些自反应性T细胞避免被破坏,而是分化成专门的调节细胞。这似乎是有益的。自身反应性T细胞亚群对自我耐受性有很强的影响,可能代表控制多种自身免疫性疾病,肿瘤生长和感染的治疗干预目标。

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