Getting down to details

Caitlin Smith

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Getting down to details

机译：深入细节

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Over the past few years, genomics researchers have been getting to grips with a 'new' genome element — microRNA (miRNA). Although a small number of miRNAs have been familiar to developmental biologists for years, a plethora of miRNAs has recently been discovered in animal and plant genomes. More than 200 miRNAs have been identified in mammalian genomes, but their functions mostly remain a mystery. Silencing gene expression in a similar way to small interfering RNAs (see Nature 431, 350; 2004), mammalian miRNAs are implicated in the control of cell and tissue differentiation, apoptosis, insulin secretion, fat metabolism and cancer.

机译：在过去的几年中，基因组学研究人员一直在研究“新”基因组元素-microRNA（miRNA）。尽管开发生物学家多年来已经熟悉了少数miRNA，但最近在动物和植物基因组中发现了许多miRNA。在哺乳动物基因组中已经鉴定出200多种miRNA，但其功能大多仍然是个谜。以类似于小干扰RNA的方式沉默基因表达（参见Nature 431，350; 2004），哺乳动物miRNA参与细胞和组织分化，凋亡，胰岛素分泌，脂肪代谢和癌症的控制。

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《Nature》 |2005年第7044期|p.991-994|共4页
作者
Caitlin Smith;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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7. Figure 6: (A) Tree resulted the standard MP analysis of the 98-loci supermatrix of the Great Apes (Hominidae, Primates, Mammalia) constructed using the modified summary of Lehtonen et al. (2011) (see “Materials and Methods” for the details) and a posteriori rooted relatively Papio (length = 12,092, CI = 0.7877, RI = 0.5597); 34,022 characters are constant, and the number of the parsimony-informative characters is equal to 4,311. MP BS values are provided below branches. The only characters with non-ambiguous value of the outgroup (Papio) have been saved within concatenated alignment; (B) the average consensus tree of the score 0.00084 resulted the analysis of the Hennigian forest of the 5,507 trees derived from the binary representation of the 98-loci supermatrix of the Great Apes (Hominidae, Primates, Mammalia) (see “Materials and Methods” for the details); Papio is assumed to be the best all-plesiomorphic group. “Additional…” FORESTER’s output tree file (see “Materials and Methods” for the details) selected for future analyses; (C) the average consensus tree of the score 0.00090 resulted the analysis of the Hennigian forest of the 5,339 trees derived from the modified binary representation of the 98-loci supermatrix of the Great Apes (Hominidae, Primates, Mammalia) (see 6.I. and “Materials and Methods” for the details), but with all 168 trees, which contain the clade (Homo plus Pan) have been removed from the input forest. “Additional…” FORESTER’s output tree file (see “Materials and Methods”) selected for future analyses. [O] . -1

机译：图6：（A）树导致的标准MP分析的98-基因座的类人猿（人科，灵长类动物，哺乳动物），使用莱赫托宁等人的修改的摘要构成的超级矩阵。（2011）（参见细节“材料和方法”）以及相对植根狒狒后验概率（长度= 12092，CI = 0.7877，RI = 0.5597）; 34022个字符是恒定的，并且简约信息的字符数等于4311。下面提供分支MP BS值。与外类群（狒狒）的非模糊值的唯一的字符已被保存的级联对准内; （B）的得分0.00084的平均一致树导致从巨猿（原始人类，灵长类动物，哺乳动物）的98座超级矩阵的二进制表示获得的5507棵的Hennigian森林的分析（见“材料和方法”为细节）;狒狒被认为是最好的全祖征群。 “其他...” FORESTER的输出树文件（请参阅详细信息“材料和方法”），用于进一步的分析; （C）的分数0.00090的平均一致树导致从98个位点的类人猿（人科，灵长类动物，哺乳动物）的超级矩阵（见6.I的改性二进制表示导出的5339种树木的Hennigian森林的分析以及“材料和方法”的详细说明），但所有168棵，其中包含的分支（智人加PAN）已经从输入林中删除。 “其他...” FORESTER的输出树文件（参见“材料和方法”），用于进一步的分析。

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