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Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae

机译：激酶调节的定量组装和小窝的亲自动循环

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A functional genomics approach has revealed that caveolae/raft-mediated endocytosis is subject to regulation by a large number of kinases(1). Here we explore the role of some of these kinases in caveolae dynamics. We discover that caveolae operate using principles different from classical membrane trafficking. First, each caveolar coat contains a set number (one 'quantum') of caveolin-1 molecules. Second, caveolae are either stored as in stationary multi-caveolar structures at the plasma membrane, or undergo continuous cycles of fission and fusion with the plasma membrane in a small volume beneath the surface, without disassembling the caveolar coat. Third, a switch mechanism shifts caveolae from this localized cycle to long-range cytoplasmic transport. We have identified six kinases that regulate different steps of the caveolar cycle. Our observations reveal new principles in caveolae trafficking and suggest that the dynamic properties of caveolae and their transport competence are regulated by different kinases operating at several levels.
机译：功能基因组学方法已经表明，小窝/筏介导的胞吞作用受大量激酶的调节（1）。在这里，我们探讨了其中一些激酶在小窝动力学中的作用。我们发现小窝使用不同于经典膜运输的原理进行操作。首先，每只小窝膜含有一组一定数量（一个“量子”）的小窝蛋白1分子。其次，海绵体要么以固定的多腔结构保存在质膜上，要么在不破坏海绵膜的情况下，连续进行裂变和与质膜在表面以下的小体积融合的循环。第三，转换机制将小窝细胞从该局部循环转移到长距离胞质运输。我们已经确定了六种激酶，它们调节小窝周期的不同步骤。我们的观察揭示了小窝运输的新原理，并表明小窝的动态特性及其转运能力受到在几个水平上运行的不同激酶的调节。

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