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Microstructure of a spatial map in the entorhinal cortex

机译:内嗅皮层空间图的微观结构

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The ability to find one's way depends on neural algorithms that integrate information about place, distance and direction, but the implementation of these operations in cortical microcircuits is poorly understood. Here we show that the dorsocaudal medial entorhinal cortex ( dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment. Its key unit is the 'grid cell', which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment. Grids of neighbouring cells share a common orientation and spacing, but their vertex locations ( their phases) differ. The spacing and size of individual fields increase from dorsal to ventral dMEC. The map is anchored to external landmarks, but persists in their absence, suggesting that grid cells may be part of a generalized, path-integration-based map of the spatial environment.
机译:寻路能力取决于神经算法,该算法集成了有关位置,距离和方向的信息,但是人们对皮质微电路中这些操作的实现知之甚少。在这里,我们显示了背尾内侧内嗅皮层(dMEC)包含空间环境的定向,地形组织的神经图。它的关键单元是“网格单元”,每当动物的位置与跨越环境表面的等边三角形规则网格的任何顶点重合时,该单元就会被激活。相邻单元格的网格具有相同的方向和间距,但是它们的顶点位置(其相位)不同。各个视野的间隔和大小从背侧到腹侧dMEC增加。该地图锚定到外部地标,但在不存在外部地标的情况下仍然存在,这表明网格单元可能是空间环境中基于路径积分的广义地图的一部分。

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