Rips repaired

Richard A. Steinhardt

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Rips repaired

机译：裂口修复

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In Duchenne muscular dystrophy, muscle cells die as a result of suffering many tiny membrane ruptures. A compound that increases membrane resealing can protect heart muscle cells from these effects.Degenerative muscle diseases are usually the result of defects in the cytoskeleton, the cell's internal scaffolding. This structure normally shields muscle cells from mechanical stress, protecting their membranes from tearing. People with Duchenne muscular dystrophy lack the protein dystrophin, which is an essential link in the complex of proteins that connect the cytoskeleton in the cell to a matrix of extracellular proteins. These buttresses across the membrane protect it from mechanical stress. Consequently, Duchenne dystrophic cells tend to get more r ips in their membranes than do normal muscle cells. In this issue, Yasuda et al. (page 1025) show that the addition of a chemical that aids membrane resealing can preserve dystrophic heart muscle cells from such damage, and might help to maintain heart function in vivo.

机译：在Duchenne肌营养不良症中，肌肉细胞由于遭受许多微小的膜破裂而死亡。增加膜重封的化合物可以保护心肌细胞免受这些影响。变性性肌肉疾病通常是细胞骨架缺陷（细胞内部支架）的结果。这种结构通常使肌肉细胞免受机械应力，从而保护其细胞膜免于撕裂。患有杜兴氏肌营养不良症的人缺乏蛋白质肌营养不良蛋白，它是将细胞中的细胞骨架与细胞外蛋白质基质相连的蛋白质复合物的重要组成部分。跨膜的这些支撑可防止其受到机械应力。因此，与正常的肌肉细胞相比，杜氏营养不良细胞的膜往往会产生更多的裂口。在这个问题上，Yasuda等。（第1025页）显示，添加有助于膜重封的化学物质可以保护营养不良的心肌细胞免受此类损害，并可能有助于体内维持心脏功能。

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《Nature》 |2005年第7053期|p.925|共1页
作者
Richard A. Steinhardt;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：核苷酸切除修复和转录偶联的DNA修复废除DNA损伤对转录的影响 *
2. Genome-Wide Analysis of Factors Affecting Transcription Elongation and DNA Repair: A New Role for PAF and Ccr4-Not in Transcription-Coupled Repair [J] . Hélène Gaillard, Cristina Tous, Javier Botet, PLoS Genetics . 2009,第2期

机译：影响转录伸长率和DNA修复的因素的基因组分析：PAF和CCR4的新作用 - 不转录耦合修复
3. Transcription-coupled DNA repair without the transcription-coupling repair factor [J] . Svejstrup JQ Trends in biochemical sciences . 2001,第3期

机译：没有转录偶联修复因子的转录偶联DNA修复
4. NUMERICAL COMPARISON OF EFFECTIVENESS OF REPAIR SYSTEMS BETWEEN RC BEAMS REPAIRED WITH SFRP COATING AND CFRP STRIPS [C] . Haeng-Ki Lee, Bong-Rae Kim, Sung-Kug Ha SAMPE'06 conference: creating new opportunities for the world economy . 2006

机译：SFRP涂层和CFRP条修复的RC梁修复系统的效率数值比较
5. Structural Insights on TFIIH in Transcription and DNA Repair [D] . van Eeuwen, Trevor. 2021

机译：TFIIH在转录和DNA修复中的结构见解
6. Drosophila which lacks canonical transcription-coupled repair proteins performs transcription-coupled repair [O] . Nazli Deger, Yanyan Yang, Laura A. Lindsey-Boltz, 2019

机译：狼吞虎咽缺乏规范转录偶联的修复蛋白进行转录耦合的修复
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