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Interference with Al-2-mediated bacterial cell-cell communication

机译：干扰Al-2介导的细菌细胞间通讯

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摘要

Bacteria communicate by means of chemical signal molecules called autoinducers. This process, called quorum sensing, allows bacteria to count the members in the community and to alter gene expression synchronously across the population. Quorum-sensing-controlled processes are often crucial for successful bacterial - host relationships - both symbiotic and pathogenic. Most quorum-sensing autoinducers promote intraspecies communication, but one autoinducer, called AI-2, is produced and detected by a wide variety of bacteria and is proposed to allow interspecies communication(1,2). Here we show that some species of bacteria can manipulate AI-2 signalling and interfere with other species' ability to assess and respond correctly to changes in cell population density. AI-2 signalling, and the interference with it, could have important ramifications for eukaryotes in the maintenance of normal microflora and in protection from pathogenic bacteria.
机译：细菌通过称为自动诱导剂的化学信号分子进行通讯。这个过程称为群体感应，它使细菌能够计数群落中的成员并在整个种群中同步改变基因表达。群体感应控制过程通常对于成功的细菌-宿主关系-共生和致病性至关重要。大多数群体感应自动诱导剂促进种间交流，但一种被称为AI-2的自动诱导剂由多种细菌产生和检测，并被提议用于种间交流（1,2）。在这里，我们表明某些细菌可以操纵AI-2信号传导，并干扰其他物种评估和正确响应细胞种群密度变化的能力。 AI-2信号及其干扰可能会对真核生物在维持正常微生物区系和保护免受病原菌侵害方面产生重要影响。

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