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How to make eggs and sperm

机译：如何制作卵子和精子

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摘要

Embryonic stem cells can develop into many specialized cell types in culture dishes. It now seems that they can also generate primordial germ cells, which then go on to form sperm and eggs. A fertilized egg is potentially immortal: this fusion of egg and sperm gives risc not only to a new individual, but also (theoretically at least) to an endless series of generations. Three groups now suggest that it is possible to generate both of these remarkable cells -- known collectively as germ cells -- ina culture dish. Geijsen and colleagues, writing on page 148 of this issue, and Toyooka et al., writing in Proceedings of the National Academy of Sciences, describe how they obtained sperm-like cells from mouse embryonic stem cells (ES cells) in vitro. Geijsen et al. even discouered that injecting their sperm-like cells into natural mouse eggs resulted in early embryonic development. Meanwhile, Hubner et al. reported earlier this year in Science, that they have succeeded in obtaining egg-like cells frommouse ES cells. So it is possible to produce germ cells with at least some attributes of sperm and eggs in vitro. These findings raise the possibility of deriving similar germ cells from human ES cells in culture -- an idea that raises ethical issues aswell as the prospect of unprecedented medical advances.
机译：胚胎干细胞可以在培养皿中发育成许多专门的细胞类型。现在看来，它们还可以产生原始生殖细胞，然后继续形成精子和卵。受精卵可能是不朽的：卵与精子的融合不仅使新个体有风险，而且从理论上讲也无数代。现在有三个小组提出，有可能在培养皿中同时产生这两种杰出的细胞-统称为生殖细胞。 Geijsen及其同事在此期的第148页上撰写，而Toyooka等人在《美国国家科学院院刊》上发表的文章描述了他们如何从小鼠胚胎干细胞（ES细胞）体外获得精子样细胞。 Geijsen等。甚至不相信将其精子样细胞注入天然小鼠卵中会导致早期胚胎发育。同时，Hubner等。今年早些时候，《科学》杂志报道说，他们已经成功地从小鼠ES细胞中获得了卵样细胞。因此有可能在体外产生具有精子和卵的至少某些属性的生殖细胞。这些发现增加了从培养的人类ES细胞中衍生出类似生殖细胞的可能性-这一想法引发了道德问题以及前所未有的医学进步的前景。

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  • 来源
    《Nature》 |2004年第6970期|p.106-107|共2页
  • 作者

    M. Azim Surani;

  • 作者单位

    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
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