Protein surgery

Hans-Georg Rammensee

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Protein surgery

机译：蛋白质手术

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Studies of human tumours and the immune system have revealed that cutting and pasting of proteins can generate new peptide variants. This startling finding has implications for both proteomics and immunity. Question: how many different pep-tides composed of nine ami no acids can a cell produce from a protein made up of 500 amino acids? Answer: 482 -- the first peptide consists of amino acids 1 to 9 of the protein; the second contains amino acids 2 to 10; and so on to the lastpeptide, which comprises amino acids 482 to 500.

机译：对人类肿瘤和免疫系统的研究表明，蛋白质的切割和粘贴可以产生新的肽变体。这个惊人的发现对蛋白质组学和免疫力都有影响。问题：一个细胞可以由500个氨基酸组成的蛋白质产生多少种由9种氨基酸组成的肽？答案：482-第一个肽由蛋白质的1至9位氨基酸组成；第二个包含2至10个氨基酸；然后是最后一个肽，最后一个肽包含482至500位氨基酸。

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来源
《Nature》 |2004年第6971期|p.203-204|共2页
作者
Hans-Georg Rammensee;
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作者单位

Department of Immunology, University of Tubingen, Auf der Morgensteldle 15, D-72076 Tubingen, Germany;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Use of bone morphogenetic proteins in spinal fusion surgery for older adults with lumbar stenosis: Trends, complications, repeat surgery, and charges [J] . DeyoR.A., ChingA., MatsenL., Spine . 2012,第3期

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3. SIGNIFICANTLY ELEVATED LEVELS OF PROANGIOGENIC PROTEINS IN WOUND FLUIDS AFTER COLORECTAL CANCER RESECTION ARE A LIKELY SOURCE OF THE PERSISTENTLY ELEVATED PLASMA LEVELS OF PROANGIOGENIC PROTEINS NOTED POST-SURGERY. [J] . Kumara H. Shantha, Sutton E., Bellini G., Diseases of the Colon and Rectum . 2016,第5期

机译：大肠癌切除后伤口液体中的proprogenogenic蛋白水平明显升高，这是术后后永久性升高的proprogenogenic蛋白血浆水平的来源。
4. Breast tissue cryosurgery with antifreeze proteins [C] . ASME international mechanical engineering congressand exposition . 1999

机译：乳腺组织冷冻蛋白酶用防冻蛋白
5. Development of microfluidic platform for continuous extraction of diagnostics plasma proteins from whole blood during cardiac surgery. [D] . Aran, Kiana. 2012

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6. Neurosurgery concepts: Key perspectives on regulatory proteins management of ossification of the posterior longitudinal ligament and radiosurgery for intracranial lesions [O] . Jonathan H. Sherman, Zachary A. Smith, Jin Mo Cho, 2013

机译：神经外科概念：关于调节蛋白后纵韧带骨化处理和颅内病变放射外科的关键观点
7. Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery [O] . Kudlova, Manuela, Kunes, Pavel, Kolackova, Martina, 2007

机译：心脏手术中脂多糖结合蛋白和sCD14不作为急性期蛋白产生。

Protein surgery

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