Our relative genetics

David Penny

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Our relative genetics

机译：我们的相对遗传学

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Data on the chimpanzee genome help in detecting differential selection on individual genes, and in judging whether normal microevolutionary processes are sufficient to account for human origins. Increasingly accurate versions of the human genome sequence are being produced. But to find out what biologically makes us human we also need the sequenced genome of our nearest relative, the chimpanzee, to see whether there is anything in our genetic constitution that could not have arisen by well-understood genetic processes. Last month, a selected version of the chimpanzee genome was published by Clark et al. in Science. The group sequenced about 200,000 protein-coding regions, and combined them with human sequences to give over 20,000 chimp-human gene alignments. The mouse genome was then used as an 'outgroup', standard practice in this form of analysis, to leave 7,645 chimp and human genes for comparative analysis.

机译：黑猩猩基因组的数据有助于检测单个基因的差异选择，并判断正常的微进化过程是否足以说明人类起源。人类基因组序列的精确度越来越高。但是，要找出生物学上使我们成为人类的原因，我们还需要我们最近的亲戚（黑猩猩）的测序基因组，以了解我们的遗传构成中是否存在任何人们无法理解的遗传过程所产生的东西。上个月，Clark等人发表了黑猩猩基因组的选定版本。在科学上。该小组对大约200,000个蛋白质编码区进行了测序，并将其与人类序列相结合，从而获得了20,000多个黑猩猩-人类基因比对。然后，将小鼠基因组用作这种分析形式的“外群”标准做法，只剩下7,645只黑猩猩和人类基因用于比较分析。

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《Nature》 |2004年第6971期|p.208-209|共2页
作者
David Penny;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Our relative genetics

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