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Travelling waves in the occurrence of dengue haemorrhagic fever in Thailand

机译:在泰国发生登革出血热的行波

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Dengue fever is a mosquito-borne virus that infects 50-100 million people each year. Of these infections, 200,000-500,000 occur as the severe, life-threatening form of the disease, dengue hemorrhagic fever (DHF). Large, unanticipated epidemics of DHF often overwhelm health systems. An understanding of the spatial-temporal pattern of DHF incidence would aid the allocation of resources to combat these epidemics. Here we examine the spatial-temporal dynamics of DHF incidence in a data set describing 850,000 infections occurring in 72 provinces of Thailand during the period 1983 to 1997. We use the method of empirical mode decomposition to show the existence of a spatial-temporal travelling wave in the incidence of DHF. We observe this wave in a three-year periodic component of variance, which is thought to reflect host-pathogen population dynamics. The wave emanates from Bangkok, the largest city in Thailand, moving radially at a speed of 148km per month. This finding provides an important starting point for detecting and characterizing the key processes that contribute to the spatial-temporal dynamics of DHF in Thailand.
机译:登革热是一种由蚊子传播的病毒,每年感染50-1亿人。在这些感染中,有200,000-500,000作为登革热出血热(DHF)的严重威胁生命的疾病而发生。 DHF的大范围意外流行经常使卫生系统不堪重负。对DHF发病率的时空格局的了解将有助于分配资源以抗击这些流行病。在这里,我们研究了描述1983年至1997年泰国72个省发生的850,000例感染的数据集中DHF发病率的时空动态。我们使用经验模式分解方法显示时空行波的存在在DHF的发病率中。我们在三年周期的方差中观察到此波,据认为这反映了宿主-病原菌种群动态。波浪发源于泰国最大的城市曼谷,以每月148公里的速度径向移动。这一发现为检测和表征有助于DHF时空动态的关键过程提供了重要的起点。

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