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Dual-key strategy

机译:双键策略

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摘要

Traffic flow between cellular compartments is controlled by recruitment of cytoplasmic proteins, New work exemplifies a dual-key mechanism, involving membrane lipids and proteins, that coordinates this control. Our cells contain a series of distinct compartments that do different jobs and have different properties. The membranes that clad each of these compartments -- like the plasma membrane that encases the cell -- are defined by precise molecular compositions, which are preserved despite the continuous influx and efflux of components in transit to and from other cellular locations. Precision is the hallmark of this flow of traffic, too, which must be directed appropriately between compartments. All of this is achieved, in part, by the reversiblerecruitment of regulatory proteins from other parts of the cell to specific membranes or membrane regions, A growing amount of evidence hints that membrane lipids cooperate with membrane proteins to control this recruitment. In Nature Cell Biology, Godiand colleagues reveal an example of this cooperative spirit, which helps to ensure the proper progression of cargo from one compartment -- the frans-Golgi network (TGN) -- to the cell surface.
机译:细胞区室之间的交通流是由细胞质蛋白的募集控制的。新工作例证了一种双键机制,涉及膜脂和蛋白质,它们协调了这种控制。我们的细胞包含一系列不同的隔室,它们可以完成不同的工作并具有不同的属性。覆盖每个隔室的膜-像包裹细胞的质膜-是由精确的分子组成定义的,尽管进出其他细胞位置的成分不断涌入和流出,这些分子仍能保留下来。精确度也是这种交通流的标志,必须在各个车厢之间正确引导。所有这些都部分是通过将调节蛋白从细胞其他部位可逆地招募到特定的膜或膜区域来实现的。越来越多的证据表明,膜脂质与膜蛋白协同控制这种募集。在《自然细胞生物学》中,戈迪安德的同事们展示了这种合作精神的一个例子,这有助于确保货物从一个舱室(flans-Golgi网络(TGN))到细胞表面的适当传播。

著录项

  • 来源
    《Nature》 |2004年第6988期|p.141-143|共3页
  • 作者单位
  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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