Moving towards individualized medicine with pharmacogenomics [Review]

Evans WE; Relling MV

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Moving towards individualized medicine with pharmacogenomics [Review]

机译：走向具有药物基因组学的个性化医学[综述]

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Individuals respond differently to drugs and sometimes the effects are unpredictable. Differences in DNA sequences that alter the expression or function of proteins that are targeted by drugs can contribute significantly to variation in the responses of individuals. Many of the genes examined in early studies were linked to highly penetrant, single-gene traits, but future advances hinge on the more difficult challenge of elucidating multi-gene determinants of drug response. This intersection of genomics and medicine has the potential to yield a new set of molecular diagnostic tools that can be used to individualize and optimize drug therapy.

机译：个人对药物的反应不同，有时效果是不可预测的。改变药物靶向蛋白质的表达或功能的DNA序列差异可显着影响个体反应的差异。早期研究中检查的许多基因都与高度渗透的单基因性状有关，但未来的进展取决于阐明药物反应的多基因决定因素这一更艰巨的挑战。基因组学和医学的这种交集有可能产生一套新的分子诊断工具，可用于个性化和优化药物治疗。

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来源
《Nature》 |2004年第6990期|p.464-468|共5页
作者
Evans WE; Relling MV;
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作者单位

Evans WE, St Jude Childrens Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Gene-expression; Drug response; Interindividual differences; Metabolism; Leukemia; Mercaptopurine; Debrisoquine; Deficient.;

机译：基因表达;药物反应;个体差异;代谢;白血病;巯基嘌呤;去甲异喹;缺陷。;

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Moving towards individualized medicine with pharmacogenomics [Review]

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