• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Resilient circadian oscillator revealed in individual cyanobacteria
【24h】

Resilient circadian oscillator revealed in individual cyanobacteria

机译：个体蓝藻中发现有弹性的昼夜节律振荡器

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Circadian oscillators, which provide internal daily periodicity, are found in a variety of living organisms, including mammals, insects, plants, fungi and cyanobacteria(1). Remarkably, these biochemical oscillators are resilient to external and internal modifications, such as temperature and cell division cycles. They have to be 'fluctuation ( noise) resistant'(2) because relative fluctuations in the number of messenger RNA and protein molecules forming the intracellular oscillators are likely to be large. In multicellular organisms, the strong temporal stability of circadian clocks, despite molecular fluctuations, can easily be explained by intercellular interactions(3-5). Here we study circadian rhythms and their stability in unicellular cyanobacteria Synechoccocus elongatus. Low-light-level microscopy has allowed us to measure gene expression under circadian control in single bacteria, showing that the circadian clock is indeed a property of individual cells. Our measurements show that the oscillators have a strong temporal stability with a correlation time of several months. In contrast to many circadian clocks in multicellular organisms, this stability seems to be ensured by the intracellular biochemical network, because the interactions between oscillators seem to be negligible.
机译：在包括哺乳动物，昆虫，植物，真菌和蓝细菌在内的各种生物中都可以发现昼夜节律，这种昼夜节律提供内部的每日周期性。值得注意的是，这些生化振荡器对外部和内部修改（例如温度和细胞分裂周期）具有弹性。它们必须“抗波动（抗噪音）”（2），因为形成细胞内振荡器的信使RNA和蛋白质分子数量的相对波动可能很大。在多细胞生物中，尽管存在分子波动，但昼夜节律的强大的时间稳定性很容易用细胞间的相互作用来解释（3-5）。在这里，我们研究昼夜节律及其在单细胞蓝藻中延伸的稳定性。弱光显微镜使我们能够在单个细菌的昼夜节律控制下测量基因表达，这表明昼夜节律确实是单个细胞的特性。我们的测量表明，振荡器具有很强的时间稳定性，相关时间为几个月。与多细胞生物中的许多生物钟不同，这种稳定性似乎是由细胞内生化网络确保的，因为振荡器之间的相互作用似乎可以忽略不计。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号