From rags to research

Carina Dennis

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From rags to research

机译：从破烂到研究

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Hunger focuses the mind. And hunger is what Mario Capecchi remembers most from his early childhood, which was spent on the streets of war-torn Italy. Today a contender for a Nobel prize, the geneticist attributes the single-minded-ness and fearlessness that has underpinned his scientific success to this formative struggle for survival. Capecchi, who works at the University of Utah in Salt Lake City, is feted for his contribution to methods for selectively knocking out genes in mice - widely used to investigate gene function and to create animal models to study human disease. Yet while he was conducting the experiments that made his name, none of Capecchi's peers knew of his harrowing childhood experiences.

机译：饥饿使思想集中。饥饿是马里奥·卡佩奇（Mario Capecchi）在童年时代最记得的东西，童年是在饱受战争war的意大利街头度过的。如今，这位遗传学家已成为诺贝尔奖的争夺者，他将一心一意和无所畏惧归功于这场为生存而进行的形成性奋斗，奠定了他的科学成功。卡佩奇（Capecchi）在盐湖城犹他大学（University of Salt Lake City）工作，他对选择性敲除小鼠基因的方法做出了贡献，该方法被广泛用于研究基因功能和创建用于研究人类疾病的动物模型。然而，在他进行实验的过程中，卡佩奇的同行们都不知道他的童年经历令人痛苦。

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《Nature》 |2004年第6995期|p.10-11|共2页
作者
Carina Dennis;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Homozygous deletion of RAG1 RAG1 , RAG2 RAG2 and 5′ region TRAF6 TRAF6 causes severe immune suppression and atypical osteopetrosis [J] . Weisz Hubshman M., Basel‐Vanagaite L., Krauss A., Clinical Genetics: An International Journal of Genetics in Medicine . 2017,第6期

机译：Rag1 Rag1，Rag2 rag2和5'区域Traf6 Traf6的纯合缺失导致严重免疫抑制和非典型骨质抑制症
2. Differential Reactions of Soybean Isolines With Combinations of Aphid Resistance Genes Rag1, Rag2, and Rag3 to Four Soybean Aphid Biotypes [J] . Ajayi-Oyetunde O. O., Diers B. W., Lagos-Kutz D., Journal of Economic Entomology . 2016,第3期

机译：大豆同系物与蚜虫抗性基因Rag1，Rag2和Rag3的组合对四种大豆蚜虫的差异反应
3. RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2 [J] . Nucleic Acids Research . 2016,第20期

机译：在基因组中靶向的RAG1由染色质相互作用介导的RAG1和RAG2的非核心区域介导
4. Recycling Used Polypropylene and Polyester Rags,Including Solvent Rags into Vehicle Parts [C] . David Briggs, Erwin Effler Global Plastics Environmental Conference . 2004

机译：再循环使用的聚丙烯和聚酯抹布，包括溶剂抹布进入车辆部件
5. Genetic Architecture of Antibiosis and Antixenosis Aphid Resistance in Soybean and Elucidation of the Molecular Effect of Pyramiding Rag1 and Rag2 Resistance Genes [D] . Ibore, Martha. 2017

机译：大豆抗生素和抗屈曲蚜虫抗性的遗传建筑，阐明了rag1和rag2抗性基因的分子效应
6. rag-1 and rag-2 are components of a high-molecular-weight complex and association of rag-2 with this complex is rag-1 dependent. [O] . T M Leu, D G Schatz 1995

机译：rag-1和rag-2是高分子量复合物的组成部分而rag-2与该复合物的结合取决于rag-1。
7. Novel G Proteins, Rag C and Rag D, Interact with GTP-binding Proteins, Rag A and Rag B [O] . Takeshi Sekiguchi, Eiji Hirose, Nobutaka Nakashima, 2001

机译：新的G蛋白，rag c和rag d，与gtp结合蛋白，rag a和rag b相互作用

From rags to research

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